GALNT1 and PTPRF

Number of citations of the paper that reports this interaction (PMID 9295285)
41

Data Source:
HPRD (in vitro)

		GALNT1	PTPRF
Gene Name		polypeptide N-acetylgalactosaminyltransferase 1	protein tyrosine phosphatase, receptor type, F
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Integral Component Of Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Manganese Ion Binding Carbohydrate Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Protein Complex Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine Post-translational Protein Modification Cellular Protein Metabolic Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Binding
Pathways		Post-translational protein modification O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		3 interactors: MUC1 PTPRF SEC23B	23 interactors: BCAR1 CAV1 CDH1 CTNNB1 FRS2 FYN GALNT1 INSR IRS1 IRS2 JUP LCK NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD RET SKIL TRIO ZNF512B
Entrez ID		2589	5792
HPRD ID		03781	01552
Ensembl ID		ENSG00000141429	ENSG00000142949
Uniprot IDs		Q05BM8 Q10472	P10586
PDB IDs			1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Receptor Binding Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone H4 Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Regulation Of Signal Transduction By P53 Class Mediator O-glycan Processing Regulation Of Histone Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Protein Binding Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Histone Modification Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Protein O-linked Glycosylation Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Intrinsic Apoptotic Signaling Pathway ER To Golgi Vesicle-mediated Transport Regulation Of Cell Cycle Arrest Negative Regulation Of Binding Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Growth Factor Stimulus Response To Organonitrogen Compound Response To Growth Factor Cellular Response To Organic Substance Response To Peptide Hormone Response To Peptide Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Cell Adhesion Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Indole-3-methanol Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Signaling Regulation Of Cell Death System Development Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Communication Locomotion Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cellular Component Movement Phosphatidylinositol-mediated Signaling Positive Regulation Of Glycogen Biosynthetic Process Response To Insulin Multicellular Organismal Development Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Organization Anatomical Structure Development Organ Development Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Signal Transduction
Tagcloud ?			1r abrogated blue bombesin castration cleavage clonogenic conditioned contributions docetaxel endpoints engineered lncap medium ne neuroendocrine neuropeptides neurotensin paracrine parp pc3 phenomenon principle pthrp secretions talk thoroughly trypan twofold
Tagcloud (Difference) ?			1r abrogated blue bombesin castration cleavage clonogenic conditioned contributions docetaxel endpoints engineered lncap medium ne neuroendocrine neuropeptides neurotensin paracrine parp pc3 phenomenon principle pthrp secretions talk thoroughly trypan twofold
Tagcloud (Intersection) ?