GALNT1 and MUC1

Number of citations of the paper that reports this interaction (PMID 9295285)
41

Data Source:
HPRD (in vitro)

		GALNT1	MUC1
Gene Name		polypeptide N-acetylgalactosaminyltransferase 1	mucin 1, cell surface associated
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Integral Component Of Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm	Nuclear Chromatin Extracellular Space Cytoplasm Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Manganese Ion Binding Carbohydrate Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding P53 Binding Transcription Cofactor Activity Protein Binding
	Biological Process	Protein O-linked Glycosylation O-glycan Processing Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine Post-translational Protein Modification Cellular Protein Metabolic Process	Protein O-linked Glycosylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Post-translational protein modification O-linked glycosylation of mucins O-linked glycosylation	Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Magnesium levels ( 20700443)
Protein-Protein Interactions		3 interactors: MUC1 PTPRF SEC23B	29 interactors: ABL1 APC CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70
Entrez ID		2589	4582
HPRD ID		03781	01152
Ensembl ID		ENSG00000141429	ENSG00000185499
Uniprot IDs		Q05BM8 Q10472	A5YRU5 A5YRU7 A5YRU8 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE0 A6ZIE2 A6ZIE4 A6ZIE5 A6ZIE6 A6ZIF0 B1AVQ5 B1AVQ7 B6ECB3 P15941 Q7Z538 Q7Z549 Q7Z551
PDB IDs			1SM3 2ACM 2FO4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Receptor Binding Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone H4 Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Regulation Of Signal Transduction By P53 Class Mediator O-glycan Processing Regulation Of Histone Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Protein Binding Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Histone Modification Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Protein O-linked Glycosylation Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Intrinsic Apoptotic Signaling Pathway ER To Golgi Vesicle-mediated Transport Regulation Of Cell Cycle Arrest Negative Regulation Of Binding Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cell Death Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of Immune Response Defense Response Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signaling Regulation Of Cell Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Activation Single Organismal Cell-cell Adhesion Cell Motility Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process O-glycan Processing Response To Organic Substance Positive Regulation Of Protein Metabolic Process Locomotion
Tagcloud ?			antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris
Tagcloud (Difference) ?			antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris
Tagcloud (Intersection) ?