NIPBL and TRIO

		NIPBL	TRIO
Description		NIPBL cohesin loading factor	trio Rho guanine nucleotide exchange factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytosol Integrator Complex SMC Loading Complex Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Mediator Complex Binding Histone Deacetylase Binding Cohesin Loader Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Mitotic Sister Chromatid Cohesion Brain Development Heart Development Sensory Perception Of Sound Intracellular Protein Localization Regulation Of Gene Expression Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gallbladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Cohesin Loading onto Chromatin	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Height ( 25282103 28552196 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		11 interacting genes: CBX5 CDK6 DBN1 DSCR9 HINFP MAP1LC3C PCNA PCNT PRSS23 SP100 SUMO2	13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA
Entrez ID		25836	7204
HPRD ID		10560	03537
Ensembl ID		ENSG00000164190	ENSG00000038382
Uniprot IDs		A0A590UJS4 Q6KC79	O75962
PDB IDs		6WG3 6WGE 7W1M	1NTY 2NZ8 6D8Z 7SJ4
Enriched GO Terms of Interacting Partners?		DNA Damage Response Generation Of Neurons PML Body Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Postsynaptic Cytosol Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Maintenance Of Protein Location In Cell PCNA Complex Replisome Negative Regulation Of DNA-templated Transcription G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Cell Communication By Chemical Coupling Maintenance Of Protein Location Maintenance Of Location In Cell Maintenance Of Location PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neurogenesis Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of Fas Signaling Pathway	Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity
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