FBXL2 and UBE2G1

Number of citations of the paper that reports this interaction (PubMedID 26037928)
25

Data Source:
BioGRID (pull down)

		FBXL2	UBE2G1
Description		F-box and leucine rich repeat protein 2	ubiquitin conjugating enzyme E2 G1
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GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Protein Modification Process Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)
Interacting Genes		14 interacting genes: APP AURKB CCND2 CDC34 COL7A1 EGFR IL1B NLRP3 PIK3R2 RBX1 SKP1 UBE2D1 UBE2D3 UBE2G1	24 interacting genes: AMFR APP CBL CRBN CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM2 TRIM63 UBA1 UBC UBE2E1 UBE3A ZRANB1
Entrez ID		25827	7326
HPRD ID		05736	03340
Ensembl ID		ENSG00000153558	ENSG00000132388
Uniprot IDs		B4E1B8 Q9UKC9	P62253
PDB IDs		6O60	2AWF 6D68
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Mitotic Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Cytosol Negative Regulation Of Cell Communication Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Cul7-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Signal Transduction Cell Cycle Phase Transition Regulation Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Cellular Response To Oxygen-containing Compound Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Astrocyte Activation Positive Regulation Of Cell Cycle Checkpoint Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Response To Light Stimulus	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Protein Polyubiquitination Macromolecule Catabolic Process Protein Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein Monoubiquitination Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin-specific Protease Binding Zinc Ion Binding Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Signal Transduction Protein Alpha-1,2-demannosylation Metal Ion Binding Protein Deglycosylation Regulation Of Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Endoplasmic Reticulum Quality Control Compartment Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Catabolic Process ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Necrotic Cell Death Regulation Of Post-translational Protein Modification Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification
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