FBXL2 and CDC34

Number of citations of the paper that reports this interaction (PMID 23604317)
3

Data Source:
BioGRID (pull down)

		FBXL2	CDC34
Gene Name		F-box and leucine-rich repeat protein 2	cell division cycle 34
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AURKB CCND2 CDC34 COL7A1 PIK3R2 SKP1 UBE2D3	45 interactors: ANAPC11 ATF5 BTRC CCNE1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCH1 MARCH2 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARG RBX1 RELA RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM21 TRIM28 UBA1 UBB VHL WWP2 ZFAND6 ZNRF1
Entrez ID		25827	997
HPRD ID		05736	00306
Ensembl ID		ENSG00000153558	ENSG00000099804
Uniprot IDs		Q9UKC9	P49427
PDB IDs			2OB4 3RZ3
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Monoubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Protein Ubiquitination Proteolysis Response To Growth Factor Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Process Histone H3-S28 Phosphorylation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Polyubiquitination Spindle Stabilization Abscission Positive Regulation Of Inclusion Body Assembly Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Negative Regulation Of CAMP-mediated Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cytokinesis Protein Localization To Kinetochore Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Histone H2A Monoubiquitination Histone H2A Ubiquitination Histone-serine Phosphorylation Regulation Of Metabolic Process Histone Modification Regulation Of Inclusion Body Assembly Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Histone Monoubiquitination Cell Division	Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Viral Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Protein Monoubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Gene Expression Cell Cycle Phase Transition Cellular Response To Oxygen Levels Cellular Response To Stimulus Regulation Of Protein Catabolic Process Response To Stimulus Cellular Response To Stress Regulation Of Protein Stability Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of RNA Biosynthetic Process Cell Cycle Regulation Of Transcription, DNA-templated Apoptotic Process Regulation Of Nucleic Acid-templated Transcription G1/S Transition Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Programmed Cell Death Regulation Of Protein Metabolic Process
Tagcloud ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1	apparatus assemble associates box cdk cdk2 cerevisiae clock conjugating conjugation cul cullin dependency e3 facilitates governed imply ligase multiprotein p19 p45 periodic saccharomyces scf scfcdc4 skp1 skp2 tight ubiquitin
Tagcloud (Difference) ?		abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c rabgef1 sh3kbp1 snp snx8 synj1 xpo1 xrn1	apparatus assemble associates box cdk cdk2 cerevisiae clock conjugating conjugation cul cullin dependency e3 facilitates governed imply ligase multiprotein p19 p45 periodic saccharomyces scf scfcdc4 skp1 skp2 tight ubiquitin
Tagcloud (Intersection) ?