FBXL2 and CDC34

Number of citations of the paper that reports this interaction (PubMedID 34635651)
65

Data Source:
BioGRID (pull down)

		FBXL2	CDC34
Description		F-box and leucine rich repeat protein 2	cell division cycle 34, ubiquitin conjugating enzyme
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GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Protein Modification Process Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of NLRP3 Inflammasome Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways			Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)
Interacting Genes		14 interacting genes: APP AURKB CCND2 CDC34 COL7A1 EGFR IL1B NLRP3 PIK3R2 RBX1 SKP1 UBE2D1 UBE2D3 UBE2G1	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		25827	997
HPRD ID		05736	00306
Ensembl ID		ENSG00000153558	ENSG00000099804
Uniprot IDs		B4E1B8 Q9UKC9	P49427
PDB IDs		6O60	2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Mitotic Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Cytosol Negative Regulation Of Cell Communication Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Cul7-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Signal Transduction Cell Cycle Phase Transition Regulation Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Cellular Response To Oxygen-containing Compound Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Astrocyte Activation Positive Regulation Of Cell Cycle Checkpoint Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Response To Light Stimulus	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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