SERPINA1 and ADAMTS4

Number of citations: 0 (PubMedID 16099106)
Data Source: HPRD (two hybrid, in vivo)

		SERPINA1	ADAMTS4
Name		serpin family A member 1	ADAM metallopeptidase with thrombospondin type 1 motif 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Acute-phase Response Blood Coagulation Hemostasis	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		Alpha-1-antitrypsin (A1AT) deficiency	None
GWAS		Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 34315874 33339817 ) Alanine transaminase levels ( 28887542 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30679032 30643258 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 28029757 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 ) Bitter alcoholic beverage consumption ( 31046077 ) Blood protein levels ( 23696881 ) Brain morphology (MOSTest) ( 32665545 ) Breast size ( 27182965 ) C-reactive protein levels ( 33227023 30388399 ) Cirrhosis (alcohol related) ( 32853455 ) Cirrhosis (multi-trait analysis) ( 33310085 ) Coronary artery disease ( 29212778 ) Gallstone disease ( 30504769 ) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273 ) Height ( 29782485 28552196 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Large artery stroke ( 28265093 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Manganese levels ( 26025379 ) Metabolite levels ( 22916037 ) Myocardial infarction ( 33532862 ) Platelet count ( 27863252 ) Plateletcrit ( 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33339817 31666285 ) Serum alpha-fetoprotein levels ( 31666285 ) Sucrose liking ( 31005972 ) Total cholesterol levels ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 )	Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Asthma ( 27182965 31361310 31619474 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Family history of Alzheimer's disease ( 30617256 ) HDL cholesterol levels ( 32203549 ) Monocyte percentage of white cells ( 27863252 32888494 )
Interacting Genes		30 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GLP1R GSDMB HSP90AA1 KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		5265	9507
HPRD ID		02463	04853
Ensembl ID		ENSG00000197249	ENSG00000158859
Uniprot IDs		A0A024R6N5 A0A384MDQ7 E9KL23 P01009	O75173
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7AEL 7API 7NPK 7NPL 8API 8P4J 8P4U 8PI2 8QZ5 8R13 8R21 9API	2RJP 3B2Z 4WK7 4WKE 4WKI
GO Terms Enriched among Interactors		Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Proteolysis Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Hydrolase Activity Protein Metabolic Process Extracellular Space Collagen Catabolic Process Extracellular Region Collagen Metabolic Process Digestion Metalloendopeptidase Activity Secretory Granule Catabolic Process Macromolecule Metabolic Process Antibacterial Peptide Biosynthetic Process Response To Other Organism Positive Regulation Of Antibacterial Peptide Production Azurophil Granule Lumen Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Antimicrobial Humoral Response Response To External Biotic Stimulus Signal Recognition Particle Binding Metallopeptidase Activity Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Response To Stress Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Antimicrobial Humoral Response Neutrophil-mediated Killing Of Bacterium Antimicrobial Humoral Response Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Protein Maturation Regulation Of Retrograde Protein Transport, ER To Cytosol Protein Processing Regulation Of Defense Response To Bacterium Defense Response Endopeptidase Activity Defense Response To Gram-negative Bacterium Positive Regulation Of Humoral Immune Response Response To Bacterium Neutrophil Mediated Immunity	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing