DSG1 and PKP1

Number of citations of the paper that reports this interaction (PMID 9606214)
47

Data Source:
HPRD (in vitro)

		DSG1	PKP1
Gene Name		desmoglein 1	plakophilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Intermediate Filament Plasma Membrane Desmosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Toxic Substance Binding Gamma-catenin Binding	Signal Transducer Activity Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Signal Transduction Multicellular Organismal Development Single Organismal Cell-cell Adhesion Intermediate Filament Bundle Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase	Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Eosinophilic esophagitis (pediatric) ( 20208534)	Panic disorder ( 19165232)
Protein-Protein Interactions		7 interactors: DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3	8 interactors: DSC1 DSG1 DSP KRT14 KRT8 TNS2 UCHL5 VIM
Entrez ID		1828	5317
HPRD ID		00515	03579
Ensembl ID		ENSG00000134760	ENSG00000081277
Uniprot IDs		Q02413	Q13835
PDB IDs			1XM9
Enriched GO Terms of Interacting Partners?		Desmosome Assembly Bundle Of His Cell To Purkinje Myocyte Communication Desmosome Organization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Single Organismal Cell-cell Adhesion Cell Adhesion Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Intermediate Filament Bundle Assembly Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Cell-cell Junction Assembly Regulation Of Muscle Contraction Regulation Of Heart Contraction Intermediate Filament Organization Cell Junction Assembly Cell-cell Junction Organization Regulation Of Membrane Potential Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament-based Process Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Cellular Component Movement Protein Localization To Plasma Membrane Endothelial Cell-cell Adhesion Adherens Junction Maintenance Cellular Component Assembly Cellular Response To Indole-3-methanol Maintenance Of Organ Identity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Plasma Membrane Organization Establishment Of Protein Localization To Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Tight Junction Assembly Cytoskeletal Anchoring At Plasma Membrane Cytoskeleton Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cell-cell Signaling Involved In Cardiac Conduction Protein Localization To Membrane Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cell Fate Specification	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Anatomical Structure Development Apoptotic Process Programmed Cell Death Response To Stimulus Cell Death Developmental Process Death Cytoskeleton Organization System Development Epithelial Cell Differentiation Ventricular Compact Myocardium Morphogenesis Multicellular Organismal Development Organ Development Protein Localization To Adherens Junction Intermediate Filament Bundle Assembly Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Organization Response To Hydrostatic Pressure Bergmann Glial Cell Differentiation Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Cell Junction Signaling Central Nervous System Development Epidermis Development Cell Communication Hemidesmosome Assembly Desmosome Organization Epithelium Development Response To Muscle Activity Cell Adhesion Hepatocyte Apoptotic Process Lens Fiber Cell Development Ventricular Cardiac Muscle Cell Action Potential Forebrain Morphogenesis Astrocyte Development Regulation Of Heart Rate By Cardiac Conduction Lateral Ventricle Development
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsc3 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmosomal displaying dsc1 dsc2 dsc3 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?		desmoplakin desmosomes