TNFAIP8 and TIFA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TNFAIP8	TIFA
Description		TNF alpha induced protein 8	TRAF interacting protein with forkhead associated domain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding
	Biological Process	Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Homooligomerization
Pathways		PI Metabolism	TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059 31959851 31619474 31361310) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heschl's gyrus morphology ( 25130324) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 28552196) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494)	Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		11 interacting genes: ATN1 EAF1 EAPP INO80E MED4 PLEKHF1 PLEKHF2 PRR13 SDCBP TIFA TMEM132D	25 interacting genes: ALPK1 AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP3 TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2
Entrez ID		25816	92610
HPRD ID		18204	09835
Ensembl ID		ENSG00000145779	ENSG00000145365
Uniprot IDs		B3KUI2 O95379	Q96CG3
PDB IDs			4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Identical Protein Binding Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Interleukin-33-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Interleukin-2 Production CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Death Programmed Cell Death Immune Response-regulating Signaling Pathway Intracellular Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
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