COX5A and EPM2A

Number of citations of the paper that reports this interaction (PubMedID 26493215)
30

Data Source:
BioGRID (two hybrid)

		COX5A	EPM2A
Description		cytochrome c oxidase subunit 5A	EPM2A glucan phosphatase, laforin
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Perikaryon Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding	Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Carbohydrate Phosphatase Activity Carbohydrate Binding Polysaccharide Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Glycogen Binding Starch Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport	Autophagosome Assembly Regulation Of Cell Growth Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Calcium Ion Transport Autophagy Mitochondrion Organization Nervous System Development Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Glial Cell Proliferation L-glutamate Transmembrane Transport Wnt Signaling Pathway Positive Regulation Of Macroautophagy Dephosphorylation Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Negative Regulation Of Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Carbohydrate Phosphorylation Habituation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs		Cholic Acid N-Formylmethionine
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		9 interacting genes: COPS6 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF	15 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		9377	7957
HPRD ID		04799	06345
Ensembl ID		ENSG00000178741	ENSG00000112425
Uniprot IDs		P20674	O95278
PDB IDs		5Z62	4R30 4RKK
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Dibenzo-p-dioxin Metabolic Process Arachidonate Monooxygenase Activity Response To Copper Ion Coumarin Metabolic Process Insecticide Metabolic Process Response To Diphenyl Ether Developmental Process Ethylene Metabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Lung Goblet Cell Differentiation Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Heme Binding Response To Iron(III) Ion Demethylase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity Habituation Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Glandular Epithelial Cell Development Long-chain Fatty Acid Omega-hydroxylase Activity Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Intermediate Filament Chorionic Trophoblast Cell Differentiation Nonassociative Learning Negative Regulation Of Dephosphorylation Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Exoribonuclease Complex	AMP-activated Protein Kinase Activity Regulation Of Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Glycogen Biosynthetic Process Protein Localization To Lipid Droplet Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Glycogen Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Phosphatase Type 1 Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Glycogen Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Response To Hormone Fatty Acid Biosynthetic Process Response To Glucose Chromatin Remodeling Polysaccharide Biosynthetic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein Phosphatase 1 Binding Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Response To Monosaccharide Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Translation Positive Regulation Of Small Molecule Metabolic Process Response To Carbohydrate Macromolecule Metabolic Process Nuclear Speck Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process
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