COX5A and HTRA1

Number of citations of the paper that reports this interaction (PMID 15101818)
18

Data Source:
HPRD (two hybrid)

		COX5A	HTRA1
Gene Name		cytochrome c oxidase subunit Va	HtrA serine peptidase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Extracellular Vesicular Exosome	Extracellular Space Cytosol Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Cytochrome-c Oxidase Activity Electron Carrier Activity Metal Ion Binding	Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding Serine-type Peptidase Activity
	Biological Process	Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Hydrogen Ion Transmembrane Transport	Regulation Of Cell Growth Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Dentinogenesis
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707)	Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Age-related macular degeneration (wet) ( 17053108)
Protein-Protein Interactions		6 interactors: COPS6 COX1 EXOSC8 HTRA1 KRT31 KRT40	18 interactors: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM46A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 NOS3 PARD6B XIAP
Entrez ID		9377	5654
HPRD ID		04799	03725
Ensembl ID			ENSG00000166033
Uniprot IDs		P20674	Q92743
PDB IDs			2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?			Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Presynaptic Membrane Organization Anatomical Structure Morphogenesis Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Cell Motility Endochondral Ossification Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Presynaptic Membrane Organization Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Neuron Differentiation Cell Morphogenesis Involved In Differentiation Limb Morphogenesis Neurogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Cartilage Development Regulation Of Signaling Limb Development Collagen Fibril Organization Collagen Catabolic Process Artery Development Neuron Projection Development Regulation Of Cell Development Cellular Response To Organic Substance Cardiovascular System Development Blood Vessel Development Connective Tissue Development Collagen Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Differentiation Endochondral Bone Morphogenesis Endothelial Tube Morphogenesis Vasculature Development Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Skeletal System Development Multicellular Organismal Metabolic Process Neuron Development Regulation Of Apoptotic Process Axon Development
Tagcloud ?		aldoa atp5a1 atp5b atp5h cox5b dlst eno1 etc fbp1 glycolysis idh2 idh3a nduf2 ndufa5 ndufb10 ndufs1 ogdh organelles oxphos pgk1 rab sdha spatio suclag2 taldo1 tca uqcrh uqrb uqrc2	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Difference) ?		aldoa atp5a1 atp5b atp5h cox5b dlst eno1 etc fbp1 glycolysis idh2 idh3a nduf2 ndufa5 ndufb10 ndufs1 ogdh organelles oxphos pgk1 rab sdha spatio suclag2 taldo1 tca uqcrh uqrb uqrc2	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Intersection) ?