CBY1 and DDIAS

Number of citations of the paper that reports this interaction (PubMedID 28079882)
30

Data Source:
BioGRID (two hybrid)

		CBY1	DDIAS
Description		chibby 1, beta catenin antagonist	DNA damage induced apoptosis suppressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Centriole Cytosol Cytoskeleton Cilium Nuclear Speck Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection	Nucleus Cytoplasm
	Molecular Function	Protein Binding Beta-catenin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Localization Cell Projection Organization Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Floor Plate Development Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Protein Homotetramerization Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cilium Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of DNA Stability Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		18 interacting genes: AGTPBP1 CDK6 CFAP53 CIBAR1 CLU CTNNB1 DDIAS DZIP1L ENKD1 FAM161B GORASP2 LNX1 NBPF11 RALBP1 RASSF10 TNFAIP8L3 TSG101 TTC23L	10 interacting genes: ACLY ACTN1 ACTN4 CBY1 ECM1 EFEMP1 FBLN1 MAF1 MIF4GD PLSCR1
Entrez ID		25776	220042
HPRD ID		09676	08062
Ensembl ID		ENSG00000100211	ENSG00000165490
Uniprot IDs		Q9Y3M2	B4DMA1 Q8IXT1
PDB IDs		4WRQ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Spindle Pole Ciliary Basal Body Cilium Cilium Organization Centriole Cytoplasm Centrosome Organelle Assembly Microtubule Cytoskeleton Cilium Assembly Establishment Of Organelle Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Ciliary Transition Zone Cell Projection Cyclin D3-CDK6 Complex T Cell Differentiation In Thymus Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Establishment Of Protein Localization To Vacuole Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Cellular Component Assembly Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Organelle Localization Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Extracellular Transport Positive Regulation Of Ubiquitin-dependent Endocytosis Doxorubicin Transport	Extracellular Exosome Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Calcium Ion Binding Pseudopodium Extracellular Matrix Structural Constituent Regulation Of Macromolecule Biosynthetic Process Integrin Binding Regulation Of Gene Expression Regulation Of Primary Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Macromolecule Metabolic Process ATP Citrate Synthase Activity Extracellular Region Regulation Of DNA-templated Transcription Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of RNA Biosynthetic Process Cortical Actin Cytoskeleton Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion RNA Polymerase III Core Binding Platelet Alpha Granule Lumen Platelet Activation Extracellular Space Regulation Of RNA Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Nucleoside Binding Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Cell Development Positive Regulation Of Sodium:proton Antiporter Activity Stress Fiber Platelet Morphogenesis Structural Constituent Of Postsynapse Extracellular Matrix Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Epidermal Growth Factor Receptor Activity Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone MRNA Stem-loop Binding Complex RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Identical Protein Binding Citrate Metabolic Process Negative Regulation Of Transcription By RNA Polymerase III Z Disc Transmembrane Transporter Binding
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