CBY1 and CIBAR1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		CBY1	CIBAR1
Description		chibby 1, beta catenin antagonist	CBY1 interacting BAR domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Centriole Cytosol Cytoskeleton Cilium Nuclear Speck Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Centriole Microtubule Organizing Center Cytoskeleton Cilium Membrane Mitochondrial Crista Motile Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Sperm Annulus Ciliary Base
	Molecular Function	Protein Binding Beta-catenin Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Phospholipid Binding
	Biological Process	Intracellular Protein Localization Cell Projection Organization Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Floor Plate Development Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Protein Homotetramerization Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cilium Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Inner Mitochondrial Membrane Organization Spermatogenesis Cell Projection Organization Cell Differentiation Limb Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Membrane Organization Membrane Tubulation
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		18 interacting genes: AGTPBP1 CDK6 CFAP53 CIBAR1 CLU CTNNB1 DDIAS DZIP1L ENKD1 FAM161B GORASP2 LNX1 NBPF11 RALBP1 RASSF10 TNFAIP8L3 TSG101 TTC23L	4 interacting genes: APPBP2 CBY1 CBY2 SHANK3
Entrez ID		25776	137392
HPRD ID		09676	14061
Ensembl ID		ENSG00000100211	ENSG00000188343
Uniprot IDs		Q9Y3M2	A1XBS5
PDB IDs		4WRQ	8CEG
Enriched GO Terms of Interacting Partners?		Cytoskeleton Spindle Pole Ciliary Basal Body Cilium Cilium Organization Centriole Cytoplasm Centrosome Organelle Assembly Microtubule Cytoskeleton Cilium Assembly Establishment Of Organelle Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Ciliary Transition Zone Cell Projection Cyclin D3-CDK6 Complex T Cell Differentiation In Thymus Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Establishment Of Protein Localization To Vacuole Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Cellular Component Assembly Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Organelle Localization Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Extracellular Transport Positive Regulation Of Ubiquitin-dependent Endocytosis Doxorubicin Transport	Ciliary Membrane Cytoplasmic Vesicle Membrane Wnt Signaling Pathway Cilium Organization Plasma Membrane Bounded Cell Projection Organization Cilium Assembly Cell Projection Floor Plate Development Cell Projection Organization Organelle Assembly Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Volume Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering GABAergic Neuron Differentiation Neurotransmitter-gated Ion Channel Clustering Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Striatal Medium Spiny Neuron Differentiation Postsynaptic Specialization Assembly Negative Regulation Of Centrosome Duplication MKS Complex Filamin Binding Plasma Membrane Bounded Cell Projection Assembly Auditory Behavior Cell Projection Assembly Regulation Of Long-term Synaptic Depression Mechanosensory Behavior Cul2-RING Ubiquitin Ligase Complex Dendritic Spine Morphogenesis Cytoskeleton Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Positive Regulation Of Long-term Synaptic Potentiation Proteasomal Protein Catabolic Process Postsynaptic Specialization Organization Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Cytoskeleton Organization
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