PRPF40B and MECP2

Number of citations of the paper that reports this interaction (PMID 14618241)
20

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PRPF40B	MECP2
Gene Name		PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	methyl CpG binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Speck	Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytosol
	Molecular Function		DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	MRNA Processing RNA Splicing	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Glutamine Metabolic Process Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Pathogenesis Post-embryonic Development Dendrite Development Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Negative Regulation Of Histone Methylation Cardiolipin Metabolic Process Negative Regulation Of Histone Acetylation Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS			Red blood cell traits ( 23446634)
Protein-Protein Interactions		3 interactors: HLA-DRA HTT MECP2	17 interactors: DNMT1 GTF2B HDAC1 HIPK2 HIST2H3A HMGB1 LBR NCOR1 PRPF40A PRPF40B RNF4 SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1
Entrez ID		25766	4204
HPRD ID		11044	02050
Ensembl ID		ENSG00000110844	ENSG00000169057
Uniprot IDs		F8VU11 Q6NWY9	D3YJ43 P51608 Q59FJ6
PDB IDs			1QK9 3C2I
Enriched GO Terms of Interacting Partners?		Cognition Monoamine Transport Social Behavior Visual Learning Visual Behavior Associative Learning Memory Learning Neurological System Process Neural Plate Formation Regulation Of Synaptic Plasticity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Death Serotonin Uptake Polysaccharide Assembly With MHC Class II Protein Complex Lactate Biosynthetic Process From Pyruvate Locomotory Behavior Regulation Of Neuron Apoptotic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Learning Or Memory Regulation Of Membrane Potential Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Response To Hypoxia Catecholamine Secretion Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission Blood Circulation Cellular Component Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Lactate Biosynthetic Process Proprioception Response To Light Stimulus Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity MHC Class II Protein Complex Assembly Paraxial Mesoderm Formation Quinolinate Metabolic Process Cellular Response To CGMP Response To CGMP Serotonin Transport Sperm Ejaculation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Neural Plate Morphogenesis L-glutamate Import Response To Radiation Single-organism Behavior Cellular Amino Acid Metabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Chromatin Modification Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Chromosome Organization Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding Cellular Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Cellular Component Organization Positive Regulation Of DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta
Tagcloud ?		acquisition alleles aml appraise asxl1 discuss dnmt3a idh1 improvements machinery malignancies mll myelogenous past prognostication quo relapse sf1 sf3a1 sf3b1 somatic spliceosomal srsf2 stratification tet2 u2af1 u2af2 unveiled zrsr2	ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		acquisition alleles aml appraise asxl1 discuss dnmt3a idh1 improvements machinery malignancies mll myelogenous past prognostication quo relapse sf1 sf3a1 sf3b1 somatic spliceosomal srsf2 stratification tet2 u2af1 u2af2 unveiled zrsr2	ache ahr antimirs arguing cholinergic cns correlates creb detrusor ep300 influences jarid1a limits micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Intersection) ?