PRPF40B and FUBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRPF40B	FUBP1
Description		pre-mRNA processing factor 40B	far upstream element binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus U1 SnRNP Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression
Pathways
Drugs			Irofulven Sacituzumab govitecan
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)	A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Hip circumference adjusted for BMI ( 34021172) Lung cancer in never smokers ( 28604730) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: FUBP1 HLA-DRA HTT MECP2 RNF10	25 interacting genes: AIMP2 ANXA11 CCNH CEBPA CELF1 CHD3 CRMP1 ESR1 GTF2H1 IMMT MAPK1IP1L MYOC PRPF40B PRR13 PUF60 SIRPA SMN1 SMURF2 SNRPA SNRPC TIAL1 TLE1 U2AF2 VIM VPS37C
Entrez ID		25766	8880
HPRD ID		11044	10349
Ensembl ID		ENSG00000110844	ENSG00000162613
Uniprot IDs		A0A8Z5ADK7 F8VU11 Q6NWY9	A0A384MDX9 A0A994J3Q8 B4DT31 C9JSZ1 Q96AE4
PDB IDs			1J4W 2KXH 4LIJ 6Y24 6Y2C 6Y2D 8P25
Enriched GO Terms of Interacting Partners?		Cognition Regulation Of Glial Cell Proliferation	RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing Nucleoplasm RNA Metabolic Process MRNA Processing U2-type Prespliceosome U1 SnRNP Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Metabolic Process Commitment Complex Nucleic Acid Metabolic Process U1 SnRNA Binding Nucleus Nucleobase-containing Compound Metabolic Process Transcription Factor TFIIH Core Complex Nucleic Acid Binding Transcription Factor TFIIH Holo Complex RNA Processing Transcription By RNA Polymerase I Negative Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Regulation Of MRNA Splicing, Via Spliceosome Nuclear Matrix Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Skeletal Muscle Hypertrophy Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly
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