SLC6A9

Description		solute carrier family 6 member 9
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GO Annotations	Cellular Component	Endosome Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Synaptic Vesicle Membrane Dense Core Granule Asymmetric Synapse Presynaptic Membrane Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse
	Molecular Function	Amino Acid:sodium Symporter Activity Glycine Transmembrane Transporter Activity Symporter Activity Glycine:sodium Symporter Activity Transmembrane Transporter Activity
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Glycine Transport Sodium Ion Transmembrane Transport Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Synaptic Transmission, Glycinergic Glycine Secretion, Neurotransmission Positive Regulation Of Heme Biosynthetic Process Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane
Pathways		SLC-mediated transport of neurotransmitters
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 29403010 32888494) Refractive error ( 32231278)
Novel Interacting Genes		3 novel interacting genes: NAPA PPP2R3B TP53BP1
Interacting Genes		3 interacting genes: GABRR1 PRKCA STX1A
Entrez ID		6536
HPRD ID		03010
Ensembl ID		ENSG00000196517
Uniprot IDs		B7Z3A9 B7Z3W8 B7Z589 P48067
PDB IDs		6ZBV 6ZPL 8WFI 8WFJ 8WFK 8WFL 9J8B 9J8C 9J8D
Enriched GO Terms of Interacting Partners?		Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Synaptic Vesicle Priming Presynaptic Active Zone Membrane Protein-containing Complex Binding SNARE Binding Positive Regulation Of Exocytosis Myosin Head/neck Binding Glutamatergic Synapse Presynaptic Membrane Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Membrane Organization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Membrane Fusion Regulation Of Insulin Secretion Protein Kinase C Signaling Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Histone H4K20me Methyltransferase Activity GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Exocytosis Histone H4K20me2 Reader Activity Desmosome Assembly ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Trans-synaptic Signaling GABA-A Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Synaptic Signaling GABA-A Receptor Complex Chemical Synaptic Transmission GABA-gated Chloride Ion Channel Activity Regulation Of Hormone Secretion Mitotic Nuclear Membrane Disassembly Diacylglycerol Binding Positive Regulation Of Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
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