GABRB2 and ARFGEF2

Number of citations of the paper that reports this interaction (PMID 15198677)
28

Data Source:
HPRD (two hybrid)

		GABRB2	ARFGEF2
Gene Name		gamma-aminobutyric acid (GABA) A receptor, beta 2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane Extracellular Vesicular Exosome GABA-A Receptor Complex	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Negative Regulation Of Neuron Apoptotic Process Synaptic Transmission, GABAergic Transmembrane Transport Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses	Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	9 interactors: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		2561	10564
HPRD ID		02578	09250
Ensembl ID		ENSG00000145864	ENSG00000124198
Uniprot IDs		P47870	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs			3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Protein Transport Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Protein Localization Transition Between Fast And Slow Fiber Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Histone H3-T6 Phosphorylation Response To Carbohydrate Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcineurin-NFAT Signaling Cascade Regulation Of Signaling Regulation Of Skeletal Muscle Adaptation Positive Regulation Of NFAT Protein Import Into Nucleus Calcium Ion Transport Positive Regulation Of B Cell Receptor Signaling Pathway Receptor Recycling Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Transport Negative Regulation Of Transport Lymphocyte Activation Protein Targeting Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metabolic Process Endomembrane System Organization Negative Regulation Of Glucose Transport Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Leukocyte Activation Regulation Of Transcription From RNA Polymerase II Promoter Lipoprotein Transport Intracellular Signal Transduction Skeletal Muscle Fiber Development Cellular Chemical Homeostasis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Localization In Cell Myotube Cell Development Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Synaptic Transmission Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endosome Organization Response To Amphetamine Golgi To Plasma Membrane Transport Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Process Cell Activation Negative Regulation Of Insulin Secretion	Cellular Response To Histamine Response To Histamine Cellular Response To Ammonium Ion Cellular Response To Organonitrogen Compound Negative Regulation Of CAMP-dependent Protein Kinase Activity Response To Ammonium Ion Response To Organonitrogen Compound Chloride Transmembrane Transport Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Chloride Transport Renal Water Homeostasis Innervation Cellular Response To Glucagon Stimulus Inner Ear Receptor Cell Development Inorganic Anion Transport Water Transport Fluid Transport Cochlea Development Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Transmembrane Transport Inner Ear Receptor Cell Differentiation Water Homeostasis Mechanoreceptor Differentiation Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Phospholipase Activity Anion Transmembrane Transport Positive Regulation Of Protein Glycosylation In Golgi Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Nerve Development Renal System Process Synaptic Transmission Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Organic Substance Energy Reserve Metabolic Process Positive Regulation Of Protein Glycosylation Sensory Perception Of Sound Anion Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Acylglycerol Acyl-chain Remodeling Negative Regulation Of Neuron Apoptotic Process Sensory Perception Of Mechanical Stimulus
Tagcloud ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Difference) ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Intersection) ?