GABRB2 and TRAK2

Number of citations of the paper that reports this interaction (PMID 12435728)
34

Data Source:
HPRD (in vivo, in vitro)

		GABRB2	TRAK2
Gene Name		gamma-aminobutyric acid (GABA) A receptor, beta 2	trafficking protein, kinesin binding 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane Extracellular Vesicular Exosome GABA-A Receptor Complex	Nucleus Cytoplasm Mitochondrion Early Endosome Plasma Membrane
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity	Receptor Binding Protein Binding Enzyme Binding GABA Receptor Binding
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Negative Regulation Of Neuron Apoptotic Process Synaptic Transmission, GABAergic Transmembrane Transport Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport	Regulation Of Transcription From RNA Polymerase II Promoter Protein O-linked Glycosylation Protein Targeting
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	3 interactors: GABRB2 KCNJ2 OGT
Entrez ID		2561	66008
HPRD ID		02578	09547
Ensembl ID		ENSG00000145864	ENSG00000115993
Uniprot IDs		P47870	O60296
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transport Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Protein Localization Transition Between Fast And Slow Fiber Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Histone H3-T6 Phosphorylation Response To Carbohydrate Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcineurin-NFAT Signaling Cascade Regulation Of Signaling Regulation Of Skeletal Muscle Adaptation Positive Regulation Of NFAT Protein Import Into Nucleus Calcium Ion Transport Positive Regulation Of B Cell Receptor Signaling Pathway Receptor Recycling Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Transport Negative Regulation Of Transport Lymphocyte Activation Protein Targeting Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metabolic Process Endomembrane System Organization Negative Regulation Of Glucose Transport Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Leukocyte Activation Regulation Of Transcription From RNA Polymerase II Promoter Lipoprotein Transport Intracellular Signal Transduction Skeletal Muscle Fiber Development Cellular Chemical Homeostasis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Localization In Cell Myotube Cell Development Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Synaptic Transmission Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endosome Organization Response To Amphetamine Golgi To Plasma Membrane Transport Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Process Cell Activation Negative Regulation Of Insulin Secretion	Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Relaxation Of Skeletal Muscle Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Positive Regulation Of Granulocyte Differentiation Cellular Response To Histamine Regulation Of Skeletal Muscle Contraction Synaptic Transmission, GABAergic Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Positive Regulation Of Histone H3-K27 Methylation Response To Histamine Cellular Chemical Homeostasis Histone H3-K4 Trimethylation Membrane Depolarization During Cardiac Muscle Cell Action Potential Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Repolarization Relaxation Of Cardiac Muscle Regulation Of Histone H3-K27 Methylation Potassium Ion Homeostasis Synaptic Transmission Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Homeostasis Cellular Response To Ammonium Ion Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Histone H3-K4 Methylation Potassium Ion Import Magnesium Ion Transport Regulation Of Glycolytic Process Peptidyl-lysine Trimethylation Cardiac Muscle Cell Action Potential Involved In Contraction Response To Organonitrogen Compound Positive Regulation Of Potassium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Homeostasis Histone H3-K4 Methylation Cell-cell Signaling Membrane Depolarization During Action Potential Innervation Regulation Of Rac Protein Signal Transduction Cardiac Muscle Cell Action Potential Positive Regulation Of Histone Methylation Regulation Of Potassium Ion Transmembrane Transport Inner Ear Receptor Cell Development
Tagcloud ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	ancestor armc10 armcx armcx1 cluster comparisons conservation dynamics enhancers eutherian evolved fission kif5 localise localises mammals miro1 mitochondria mitochondrial moving neuroprotective neurotransmission organisation prevents retrotransposition syntenic trafficking underscore vertebrates
Tagcloud (Difference) ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	ancestor armc10 armcx armcx1 cluster comparisons conservation dynamics enhancers eutherian evolved fission kif5 localise localises mammals miro1 mitochondria mitochondrial moving neuroprotective neurotransmission organisation prevents retrotransposition syntenic trafficking underscore vertebrates
Tagcloud (Intersection) ?