GABRB2 and TRAK2

Number of citations of the paper that reports this interaction (PubMedID 12435728)
0

Data Source:
HPRD (in vitro, in vivo)

		GABRB2	TRAK2
Description		gamma-aminobutyric acid type A receptor subunit beta2	trafficking kinesin protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Extracellular Exosome GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Nucleus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Plasma Membrane Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Axonal Growth Cone
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Binding Protein Binding Myosin Binding Kinesin Binding Enzyme Binding TPR Domain Binding GABA Receptor Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Neuron Development Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Negative Regulation Of Axonogenesis Dendritic Transport Of Mitochondrion
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Multisite chronic pain ( 31194737 33830993) Nicotine dependence symptom count ( 25555482) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Breast cancer ( 31757997) Cocaine use disorder x change in residence interaction ( 31490055)
Interacting Genes		5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	4 interacting genes: EIF4ENIF1 GABRB2 KCNJ2 OGT
Entrez ID		2561	66008
HPRD ID		02578	09547
Ensembl ID		ENSG00000145864	ENSG00000115993
Uniprot IDs		P47870	O60296
PDB IDs		6D6T 6D6U 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CXA 9CXB 9CXC 9CXD 9DRX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Transport GABA Receptor Binding Myosin Binding Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Dendrite Morphogenesis Regulation Of Synaptic Vesicle Exocytosis Establishment Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Saliva Secretion Negative Regulation Of Nervous System Development Peptidyl-serine Dephosphorylation Dendritic Spine Regulation Of Intracellular Signal Transduction Negative Regulation Of Neurogenesis Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Dendritic Transport Of Mitochondrion Regulation Of Anatomical Structure Morphogenesis Regulation Of Exocytosis Negative Regulation Of Cell Projection Organization Protein Kinase C Signaling Symmetric Synapse Endomembrane System Organization Cytoplasmic Vesicle Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Macromolecule Metabolic Process Regulation Of Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Transition Between Fast And Slow Fiber Calcium Ion Transport Cell Projection Morphogenesis Positive Regulation Of Kidney Development	Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Relaxation Of Skeletal Muscle Positive Regulation Of Cardiolipin Metabolic Process Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA GABA Receptor Activity Dendritic Spine Cellular Response To Histamine Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Positive Regulation Of Lipid Metabolic Process Regulation Of Cardiolipin Metabolic Process Mitochondrial Membrane Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translation Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Carbon Catabolite Regulation Of Transcription Postsynaptic Membrane
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