GABRB2

Description		gamma-aminobutyric acid type A receptor subunit beta2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Extracellular Exosome GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Neuron Development Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Multisite chronic pain ( 31194737 33830993) Nicotine dependence symptom count ( 25555482) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1
Entrez ID		2561
HPRD ID		02578
Ensembl ID		ENSG00000145864
Uniprot IDs		P47870
PDB IDs		6D6T 6D6U 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CXA 9CXB 9CXC 9CXD 9DRX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Transport GABA Receptor Binding Myosin Binding Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Dendrite Morphogenesis Regulation Of Synaptic Vesicle Exocytosis Establishment Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Saliva Secretion Negative Regulation Of Nervous System Development Peptidyl-serine Dephosphorylation Dendritic Spine Regulation Of Intracellular Signal Transduction Negative Regulation Of Neurogenesis Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Dendritic Transport Of Mitochondrion Regulation Of Anatomical Structure Morphogenesis Regulation Of Exocytosis Negative Regulation Of Cell Projection Organization Protein Kinase C Signaling Symmetric Synapse Endomembrane System Organization Cytoplasmic Vesicle Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Macromolecule Metabolic Process Regulation Of Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Transition Between Fast And Slow Fiber Calcium Ion Transport Cell Projection Morphogenesis Positive Regulation Of Kidney Development
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