GABRA1 and UBQLN1

Number of citations of the paper that reports this interaction (PMID 11528422)
49

Data Source:
BioGRID (two hybrid)

		GABRA1	UBQLN1
Gene Name		gamma-aminobutyric acid (GABA) A receptor, alpha 1	ubiquilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA Receptor Complex	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Drug Binding GABA Receptor Activity	Protein Binding Kinase Binding Protein Domain Specific Binding
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Synaptic Transmission, GABAergic Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Secobarbital Zolpidem Metharbital Picrotoxin Methohexital Chlordiazepoxide Amoxapine Adinazolam Thiopental Clorazepate Midazolam Flurazepam Isoflurane Primidone Halazepam Diazepam Progabide Oxazepam Methylphenobarbital Triazolam Ethanol Zaleplon Methoxyflurane Clonazepam Methyprylon Thiamylal Halothane Phenobarbital Desflurane Zopiclone Flumazenil Estazolam Sevoflurane Dihydroergotoxine Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Barbital Barbituric acid derivative Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DRD4 PPP3CA PRKCD PRKCG UBQLN1	151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343
Entrez ID		2554	29979
HPRD ID		00662	05440
Ensembl ID		ENSG00000022355	ENSG00000135018
Uniprot IDs		A8K177 P14867	Q9UMX0
PDB IDs			2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Response To Stress Chemosensory Behavior Response To Amphetamine Response To Amine Activation Of Phospholipase C Activity Defense Response Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Response To Stress Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Synaptic Transmission Response To Ammonium Ion Regulation Of Circadian Rhythm Negative Regulation Of Protein Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Mismatch Repair Transition Between Fast And Slow Fiber Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Cellular Protein Metabolic Process Cell Activation Membrane Depolarization Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Transport Regulation Of Protein Metabolic Process Regulation Of Anion Transport Response To Alkaloid Innate Immune Response Response To Organonitrogen Compound Regulation Of Mismatch Repair Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Phospholipid Catabolic Process Olfactory Learning Negative Regulation Of Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-cell Signaling Negative Regulation Of Secretion Negative Regulation Of Protein Transport Response To Organic Substance Interleukin-10 Production Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Platelet Activation	Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabrb2 gabrb3 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Difference) ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabrb2 gabrb3 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms	affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose
Tagcloud (Intersection) ?