GABRA1

Gene Name		gamma-aminobutyric acid (GABA) A receptor, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Drug Binding GABA Receptor Activity
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Synaptic Transmission, GABAergic Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Secobarbital Zolpidem Metharbital Picrotoxin Methohexital Chlordiazepoxide Amoxapine Adinazolam Thiopental Clorazepate Midazolam Flurazepam Isoflurane Primidone Halazepam Diazepam Progabide Oxazepam Methylphenobarbital Triazolam Ethanol Zaleplon Methoxyflurane Clonazepam Methyprylon Thiamylal Halothane Phenobarbital Desflurane Zopiclone Flumazenil Estazolam Sevoflurane Dihydroergotoxine Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Barbital Barbituric acid derivative Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS
Protein-protein Interactions		5 interactors: DRD4 PPP3CA PRKCD PRKCG UBQLN1
Entrez ID		2554
HPRD ID		00662
Ensembl ID		ENSG00000022355
Uniprot IDs		A8K177 P14867
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Response To Stress Chemosensory Behavior Response To Amphetamine Response To Amine Activation Of Phospholipase C Activity Defense Response Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Response To Stress Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Synaptic Transmission Response To Ammonium Ion Regulation Of Circadian Rhythm Negative Regulation Of Protein Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Mismatch Repair Transition Between Fast And Slow Fiber Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Cellular Protein Metabolic Process Cell Activation Membrane Depolarization Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Transport Regulation Of Protein Metabolic Process Regulation Of Anion Transport Response To Alkaloid Innate Immune Response Response To Organonitrogen Compound Regulation Of Mismatch Repair Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Phospholipid Catabolic Process Olfactory Learning Negative Regulation Of Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-cell Signaling Negative Regulation Of Secretion Negative Regulation Of Protein Transport Response To Organic Substance Interleukin-10 Production Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Platelet Activation
Tagcloud ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabrb2 gabrb3 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms