RNF169 and UBE2E1

Number of citations of the paper that reports this interaction (PubMedID 22492721)
36

Data Source:
BioGRID (pull down)

		RNF169	UBE2E1
Description		ring finger protein 169	ubiquitin conjugating enzyme E2 E1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization DNA Damage Response Protein Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein K48-linked Ubiquitination
Pathways			ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Academic attainment (English) ( 33594131) Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AC4 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1	116 interacting genes: ARIH2 ARK2C ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF2 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF34 RNF4 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA6 UBA7 UBASH3B UBC UBE2G1 UBE3A UBOX5 UBR5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNG1E ZNRF1 ZNRF2 ZNRF4
Entrez ID		254225	7324
HPRD ID		19383	04225
Ensembl ID		ENSG00000166439	ENSG00000170142
Uniprot IDs		Q8NCN4	B7Z306 P51965
PDB IDs		5GG4 5VEY	1XR9 3BZH 4JJQ 5LBN 6FGA 8IYA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Metabolic Process Chromatin Remodeling Centrosome Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Mitotic Spindle Assembly Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of Biosynthetic Process Cytoskeleton Chromatin Organization Protein Heterodimerization Activity Negative Regulation Of Prostaglandin Biosynthetic Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Glycosylation Microtubule Cytoskeleton Organization ISG15 Transferase Activity Activation Of Janus Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Heterochromatin Formation FHF Complex Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Golgi Disassembly ISG15-protein Conjugation Regulation Of Protein Glycosylation Barr Body Female Meiosis I Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Protein Localization To Perinuclear Region Of Cytoplasm	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Protein Metabolic Process Zinc Ion Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Macromolecule Metabolic Process Protein Autoubiquitination Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Post-translational Protein Modification Cytoplasm Positive Regulation Of Catabolic Process Ubiquitin Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Autophagy DNA Damage Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Signal Transduction Innate Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling
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