RNF169

Description		ring finger protein 169
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization DNA Damage Response Protein Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		11 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AC4 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1
Entrez ID		254225
HPRD ID		19383
Ensembl ID		ENSG00000166439
Uniprot IDs		Q8NCN4
PDB IDs		5GG4 5VEY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Metabolic Process Chromatin Remodeling Centrosome Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Mitotic Spindle Assembly Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of Biosynthetic Process Cytoskeleton Chromatin Organization Protein Heterodimerization Activity Negative Regulation Of Prostaglandin Biosynthetic Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Glycosylation Microtubule Cytoskeleton Organization ISG15 Transferase Activity Activation Of Janus Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Heterochromatin Formation FHF Complex Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Golgi Disassembly ISG15-protein Conjugation Regulation Of Protein Glycosylation Barr Body Female Meiosis I Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Protein Localization To Perinuclear Region Of Cytoplasm
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