TMEM9 and TSPO

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM9	TSPO
Name		transmembrane protein 9	translocator protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Microtubule Cytoskeleton Membrane Late Endosome Membrane Multivesicular Body Membrane Intercellular Bridge Mitotic Spindle	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity
	Biological Process	Lysosomal Lumen Acidification Protein Transport Regulation Of Protein Catabolic Process Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Assembly Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion
Pathways		None	Pregnenolone biosynthesis
Drugs		None	Chlormezanone Zopiclone
GWAS		Asthma ( 29273806 ) Metabolite levels ( 23823483 )	Metabolite levels ( 23823483 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: TSPAN15
Interacting Genes		14 interacting genes: ATP6V0C C2CD2L CLDN1 CLDN10 EMP1 GALNT6 NINJ2 PGAP2 SLC30A8 TMEM140 TMEM230 TMEM60 TRARG1 TSPO	17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1
Entrez ID		252839	706
HPRD ID		15542	15913
Ensembl ID		ENSG00000116857	ENSG00000100300
Uniprot IDs		B1ALM5 B4E1H4 Q9P0T7	O76068 P30536
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Regeneration Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Benzodiazepine Receptor Binding