DEFB124 and PGRMC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEFB124	PGRMC1
Description		defensin beta 124	progesterone receptor membrane component 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse
	Molecular Function	Protein Binding	Amyloid-beta Binding Steroid Binding Protein Binding Lipid Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Defense Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Defense Response To Bacterium Innate Immune Response Cellular Response To Peptidoglycan Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Heme Biosynthetic Process Axon Guidance Memory Associative Learning Modification Of Synaptic Structure Positive Regulation Of Lipoprotein Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Synapse Organization
Pathways		Beta defensins Defensins	Neutrophil degranulation
Drugs			Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS			Hodgkin's lymphoma ( 34216518)
Interacting Genes		2 interacting genes: NCK2 PGRMC1	20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 LINC00632 MTNR1A PAM16 SCAP SGTB TMEM213 ZNF71
Entrez ID		245937	10857
HPRD ID		18759	02338
Ensembl ID		ENSG00000180383	ENSG00000101856
Uniprot IDs		Q8NES8	O00264 Q6IB11
PDB IDs			4X8Y
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cytoskeletal Anchor Activity Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Immunological Synapse Formation Negative Regulation Of PERK-mediated Unfolded Protein Response Dendritic Spine Development Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Lipoprotein Transport Negative Regulation Of Synapse Organization Smooth Endoplasmic Reticulum Membrane Heme Biosynthetic Process Modification Of Synaptic Structure Synapse Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Steroid Binding Signaling Receptor Complex Adaptor Activity Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Projection Organization Vesicle Membrane Heme Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Porphyrin-containing Compound Metabolic Process Lamellipodium Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Tetrapyrrole Metabolic Process Cell-cell Recognition Pigment Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Scaffold Protein Binding ERBB Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Protein Localization To Cell Periphery	GET Complex
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