TXNL4B and AIPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TXNL4B	AIPL1
Description		thioredoxin like 4B	AIP like 1 HSP90 co-chaperone
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Farnesylated Protein Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Unfolded Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Retina Homeostasis Apoptotic Process Visual Perception Phototransduction, Visible Light Protein Farnesylation Regulation Of Opsin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR)
GWAS		Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 30718733 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Red blood cell count ( 32888494) Total cholesterol levels ( 30718733) Triglyceride levels ( 32154731 32203549)	C-reactive protein levels ( 29403010 33339817) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hormone measurements ( 23696881) Manganese levels ( 26025379) Paclitaxel-induced cytotoxicity ( 26015512) Reading disability ( 32108986)
Interacting Genes		13 interacting genes: AIPL1 ALKBH4 BHLHE40 MEOX1 MEOX2 PICK1 PLEKHF2 PNMA5 PRPF6 REL SF1 SPG21 TCF4	10 interacting genes: ACD HSP90AA1 HSPA8 LBX1 NUB1 PLSCR3 POT1 SMAP1 TINF2 TXNL4B
Entrez ID		54957	23746
HPRD ID		11655	05092
Ensembl ID		ENSG00000140830	ENSG00000129221
Uniprot IDs		Q9NX01	F1T0B5 F1T0B6 F1T0C0 F1T0C4 Q7Z3H1 Q9NZN9
PDB IDs		1XBS 3GIX 4IN0 8Y6O	5U9A 5U9I 5U9J 5U9K 5V35 6PX0
Enriched GO Terms of Interacting Partners?		Somite Specification Segment Specification Somite Development DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Limb Development E-box Binding Spliceosomal Complex Assembly Farnesylated Protein Binding DNA N6-methyladenine Demethylase Activity Embryonic Pattern Specification Cleavage Furrow Ingression Positive Regulation Of Transcription By RNA Polymerase II Sclerotome Development Beta-catenin-TCF7L2 Complex Protein Farnesylation	Telomere Assembly Shelterin Complex Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Capping Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Chaperone-mediated Autophagy Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase MHC Class II Protein Complex Binding Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Refolding Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Regulation Of Organelle Organization Positive Regulation Of DNA Biosynthetic Process Protein Localization To Organelle Nucleic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Chaperone-mediated Autophagy Translocation Complex Disassembly Protein Folding Chaperone DNA Metabolic Process
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