FJX1 and WT1

Data Source: HiPPIP (Novel)

		FJX1	WT1
Name		four-jointed box kinase 1	WT1 transcription factor
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	None	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell-cell Signaling Retina Layer Formation	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Nephron Tubule Morphogenesis Podocyte Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Circulatory System Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development
Pathways		None	Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development
Diseases		None	Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bone mineral density (hip) ( 30172743 ) Femoral neck bone mineral density ( 30172743 )	Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Brugada syndrome ( 35210625 ) Coronary artery disease ( 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Inguinal hernia ( 26686553 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (diuretics) ( 31015401 ) Offspring birth weight ( 31043758 ) Pelvic organ prolapse ( 32184442 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) Resting-state electroencephalogram vigilance ( 29703947 ) Rubella-specific interleukin-6 secretion ( 29253144 ) Tuberculosis ( 24057671 22306650 ) Uterine fibroids ( 31649266 31249589 30194396 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: WT1	8 novel interactors: B3GNT3 BST2 CALML5 CAPRIN1 FJX1 HIPK3 PAX6 PEX3
Interacting Genes		2 interacting genes: DKKL1 PIGN	66 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP YAP1 ZNF205 ZRANB1
Entrez ID		24147	7490
HPRD ID		16897	06163
Ensembl ID		ENSG00000179431	ENSG00000184937
Uniprot IDs		Q86VR8	A0A481V744 H0Y7K5 P19544 Q6PI38
PDB IDs		Not available	1XF7 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH 7BBG 8ISN
GO Terms Enriched among Interactors		Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Mannose-ethanolamine Phosphotransferase Activity Negative Regulation Of Testosterone Biosynthetic Process Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Regulation Of Testosterone Biosynthetic Process Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Penetration Of Zona Pellucida Receptor Antagonist Activity Co-receptor Binding Metanephric Epithelium Development Muscle Cell Fate Commitment Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Glomerulus Development C2H2 Zinc Finger Domain Binding Male Genitalia Development Mesenchymal To Epithelial Transition Positive Regulation Of Apoptotic Process Renal Tubule Morphogenesis Positive Regulation Of Programmed Cell Death Skeletal Muscle Organ Development Cellular Response To Gonadotropin Stimulus Circulatory System Development Regulation Of Ketone Biosynthetic Process Sex Determination Reproductive System Development Adrenal Gland Development Negative Regulation Of Steroid Biosynthetic Process Response To Gonadotropin GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Negative Regulation Of Steroid Metabolic Process	Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Body Nucleoplasm Regulation Of Transcription By RNA Polymerase II Cellular Response To Gamma Radiation Cellular Response To Radiation Chromatin Identical Protein Binding Epithelial Cell Proliferation Regulation Of Stem Cell Population Maintenance Regulation Of Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To UV Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Actinomycin D Cell Population Proliferation Positive Regulation Of Lymphocyte Apoptotic Process Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Response To Gamma Radiation Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Cytosol Cellular Response To Light Stimulus Response To Actinomycin D PML Body