IFIT5 and IFIT1

Number of citations of the paper that reports this interaction (PMID 21642987)
66

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IFIT5	IFIT1
Gene Name		interferon-induced protein with tetratricopeptide repeats 5	interferon-induced protein with tetratricopeptide repeats 1
Image
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Ruffle Membrane Apical Part Of Cell	Cytoplasm Cytosol
	Molecular Function	TRNA Binding RNA Binding Single-stranded RNA Binding Poly(A) RNA Binding	RNA Binding Protein Binding
	Biological Process	Innate Immune Response Defense Response To Virus	Response To Virus Intracellular Transport Of Viral Protein In Host Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus By Host Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: A2M APOE CDC37 ECSIT IFIT1 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2	4 interactors: EIF3E IFIT2 IFIT3 IFIT5
Entrez ID		24138	3434
HPRD ID		17130	00983
Ensembl ID		ENSG00000152778
Uniprot IDs		B4DDV1 Q13325	D3DR31 P09914
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U	4HOU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Response To Stress Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Cellular Response To Stimulus Negative Regulation Of Viral Process Immune Response Innate Immune Response Response To Stimulus Regulation Of Neuron Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Protein Binding Regulation Of Neuron Death Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nuclear Speck Organization Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of MRNA Splicing, Via Spliceosome Defense Response Signal Transduction Immune System Process Positive Regulation Of Neuron Death Regulation Of Oxidoreductase Activity Regulation Of Cellular Process Regulation Of Apoptotic Process Protein Metabolic Process Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of MRNA Processing Regulation Of Cell Death Signaling Regulation Of Catalytic Activity Negative Regulation Of Binding Negative Regulation Of Apoptotic Process Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of RNA Splicing Response To Oxidative Stress Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux	Cellular Response To Interferon-alpha Defense Response To Virus Response To Interferon-alpha Response To Virus Response To Other Organism Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Biotic Stimulus Response To Type I Interferon Innate Immune Response Immune Response Defense Response Response To External Stimulus Cytokine-mediated Signaling Pathway Immune System Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Response To Cytokine Stimulus Response To Cytokine Negative Regulation Of Protein Binding Response To Stress
Tagcloud ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding expand ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail
Tagcloud (Difference) ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding expand ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail
Tagcloud (Intersection) ?