RNF126 and UBE2E2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF126	UBE2E2
Description		ring finger protein 126	ubiquitin conjugating enzyme E2 E2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Protein Monoubiquitination DNA Damage Response Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 32499647 30718926 30054458 30297969 22885922 28869590 26818947 24509480 23945395) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)
Interacting Genes		42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	77 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B HERC5 IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF168 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBA6 UBOX5 WWP2 XIAP ZNRF1 ZNRF2
Entrez ID		55658	7325
HPRD ID		11501	06779
Ensembl ID		ENSG00000070423	ENSG00000182247
Uniprot IDs		A8K0Q1 Q9BV68	Q96LR5
PDB IDs		2N9O 2N9P	1Y6L 6W9A
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Cytoplasm Response To Stress Protein K6-linked Ubiquitination Immune System Process Positive Regulation Of Catabolic Process Innate Immune Response Cellular Response To Stress Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Protein Destabilization DNA Damage Response Response To Other Organism Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Defense Response
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