PRPF38B and ESS2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF38B	ESS2
Description		pre-mRNA processing factor 38B	ess-2 spliceosome associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Precatalytic Spliceosome	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding	Protein Binding
	Biological Process	MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing
Pathways
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743)
Interacting Genes		6 interacting genes: CEBPA ESS2 LSM5 RBFOX2 SRPK2 YWHAG	33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1
Entrez ID		55119	8220
HPRD ID		07664	03452
Ensembl ID		ENSG00000134186	ENSG00000100056
Uniprot IDs		A0A0A0MRN0 Q5VTL8	F8WEF8 Q96DF8
PDB IDs			8C6J 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing RNA Metabolic Process MRNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of MRNA Processing CHOP-C/EBP Complex Protein Kinase C Inhibitor Activity Intracellular Signal Transduction DNA-binding Transcription Factor Binding White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of RNA Splicing Nuclear Speck Organization Spliceosomal Complex Lsm1-7-Pat1 Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Domain Specific Binding Response To Phenylpropanoid Nucleus Presynapse Lsm2-8 Complex Fat Cell Proliferation R-loop Processing Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell U6 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Urea Cycle STAT Family Protein Binding Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Urea Metabolic Process HMG Box Domain Binding	RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding
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