POLA2 and TMEM216

		POLA2	TMEM216
Description		DNA polymerase alpha 2, accessory subunit	transmembrane protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Cell Projection
	Molecular Function	DNA Binding Protein Binding	Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus	Cell Projection Organization Cilium Assembly Non-motile Cilium Assembly
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Anchoring of the basal body to the plasma membrane
Drugs		Dacarbazine
Diseases			Joubert syndrome
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	1 interacting genes: MCM3AP
Entrez ID		23649	51259
HPRD ID		10160	14439
Ensembl ID		ENSG00000014138	ENSG00000187049
Uniprot IDs		A0A9L9PY44 H0YDR7 Q14181	J3QT25 Q9P0N5
PDB IDs		2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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