LDOC1 and SMARCB1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		LDOC1	SMARCB1
Description		LDOC1 regulator of NFKB signaling	SWI/SNF related BAF chromatin remodeling complex subunit B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nuclear Chromosome Kinetochore Chromatin Fibrillar Center XY Body Nucleus Nucleoplasm Nucleolus Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex Germ Cell Nucleus NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding
	Biological Process	Maternal Placenta Development Negative Regulation Of Cell Population Proliferation Maternal Process Involved In Parturition Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide	RNA Polymerase I Preinitiation Complex Assembly Blastocyst Development Blastocyst Hatching Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Negative Regulation Of Cell Population Proliferation DNA Integration Regulation Of Mitotic Metaphase/anaphase Transition Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Host-mediated Activation Of Viral Transcription Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Hepatocyte Differentiation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS			Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional shortening ( 29403010) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) N-glycan levels ( 31163085)
Interacting Genes		106 interacting genes: AATF ABLIM1 AEBP2 AIRIM AP1M1 AQP1 ATF4 ATP6V1G1 BARD1 BEX2 BYSL CCDC33 CCDC85B CDC5L CEBPE CFAP53 CTNNBL1 DPF2 DPPA4 ENKD1 FAM107A FAM110A FAM161A FAM193B FAM50B FAM90A1 FCHSD2 FOSL1 FXR2 GADD45GIP1 GNL3L GPANK1 HAUS1 HDAC4 HGS HOXB5 HOXC8 IKZF3 IKZF5 INPP1 IQCB1 JRK KRT15 KRT18 LATS1 LENG1 LMO2 LNX1 MBD3 MEAF6 MFAP1 MSGN1 MYC MZF1 NOD2 NRIP1 NXF1 PLEKHF2 POLL PPP1R18 PRPF18 PRPF31 PSMA1 PSMF1 RAB29 RALBP1 RASSF10 RIBC1 RNF6 RPP25 SCNM1 SDCBP SETD5 SH2D4A SMARCB1 SMARCD1 SUDS3 TASOR2 TBC1D7 TCEANC TEAD4 THAP7 TLE5 TMSB4XP1 TNNT1 TSGA10IP TSNAX TTC23 UBTFL1 UTP14A WDR25 WT1 ZBTB16 ZBTB24 ZFP1 ZGPAT ZNF124 ZNF250 ZNF408 ZNF564 ZNF587 ZNF629 ZNF648 ZNF688 ZNF774 ZNF835	111 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CXCL11 CYB5D2 DNAJA3 DPH6 EZH2 FAM90A1 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HGS HNRNPM HOMEZ HOOK2 HSF2BP HSFY1 IHO1 IKZF3 IL16 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MESD MIF4GD MRPL53 MXI1 MYC NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PICK1 PPP1CC PPP1R15A PRKAB2 PSMB1 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RUSC1 RXRA SAXO1 SIN3B SMARCA4 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TRIM35 TSC22D4 UBQLN4 UBR5 VIM XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398 ZNF688
Entrez ID		23641	6598
HPRD ID		02322	03364
Ensembl ID		ENSG00000182195	ENSG00000099956
Uniprot IDs		O95751	G5E975 Q12824 Q9H836
PDB IDs			5AJ1 5GJK 5L7A 5L7B 6AX5 6KAG 6KZ7 6LTH 6LTJ 6LZP 6UCH 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm DNA-binding Transcription Factor Activity Nuclear Speck Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Stem Cell Population Maintenance Zinc Ion Binding Positive Regulation Of Stem Cell Population Maintenance DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Spindle Pole DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Chromatin NBAF Complex Positive Regulation Of RNA Biosynthetic Process Centrosome Positive Regulation Of DNA-templated Transcription Chromatin Organization Cytoskeleton Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Protein-DNA Complex Disassembly Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Regulation Of Nucleotide-excision Repair Ribosome Biogenesis SWI/SNF Complex Positive Regulation Of Transcription By RNA Polymerase I Spliceosomal Complex	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Organelle Organization Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Intermediate Filament Organization Positive Regulation Of Macromolecule Metabolic Process Supramolecular Fiber Organization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Protein Domain Specific Binding Intermediate Filament-based Process Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Lymphocyte Apoptotic Process Structural Constituent Of Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Regulation Of Glial Cell Proliferation Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytosol Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Signal Complex Assembly
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