USP3 and DDX58

Number of citations of the paper that reports this interaction (PMID 24366338)
1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		USP3	DDX58
Gene Name		ubiquitin specific peptidase 3	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Cytoplasm Cytosol Tight Junction Actin Cytoskeleton Ruffle Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding	Double-stranded DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Histone Deubiquitination Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Positive Regulation Of Defense Response To Virus By Host Metabolic Process Detection Of Virus Response To Virus Viral Process Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways			TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS		Heart failure ( 20445134)
Protein-Protein Interactions		3 interactors: DDX58 IFIH1 UBC	13 interactors: CYLD MAVS PRKCG PRKRIR RNF135 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP3 WRNIP1
Entrez ID		9960	23586
HPRD ID		05290	13131
Ensembl ID			ENSG00000107201
Uniprot IDs		Q9Y6I4	B3KWW1 F5H5W6 O95786
PDB IDs			2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3TMI 3ZD6 3ZD7 4AY2 4BPB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type I Interferon Production Regulation Of Type III Interferon Production Detection Of Virus Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Virus Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Immune Response-regulating Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Viral Process Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RIG-I Signaling Pathway Response To Virus Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Viral Protein Processing Protein Modification By Small Protein Conjugation Positive Regulation Of Defense Response To Virus By Host Response To Other Organism Notch Receptor Processing Virion Assembly Response To Biotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Sumoylation Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Defense Response To Virus By Host Positive Regulation Of Transcription Factor Import Into Nucleus	Negative Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Response To Stress Regulation Of Innate Immune Response Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cytokine Production Immune Response Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Protein K48-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cytokine Production Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Modification Process Positive Regulation Of Immune Response Response To Stimulus Regulation Of Protein Catabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process Cellular Response To Stress Proteolysis Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?			adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Difference) ?			adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Intersection) ?