WDR6 and CDC42EP4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WDR6	CDC42EP4
Gene Name		WD repeat domain 6	CDC42 effector protein (Rho GTPase binding) 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane COP9 Signalosome	Cytoplasm Plasma Membrane Endomembrane System Actin Cytoskeleton Microtubule Cytoskeleton
	Molecular Function	Protein Binding Poly(A) RNA Binding	Rho GTPase Activator Activity GTP-Rho Binding Poly(A) RNA Binding
	Biological Process	Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BRCA1 CDC42EP4 G2E3 PTPN3	8 interactors: APP CDC42 FAM9B LNX1 RHOQ SRPK2 TGFBR1 WDR6
Entrez ID		11180	23580
HPRD ID		06912	08383
Ensembl ID		ENSG00000178252	ENSG00000179604
Uniprot IDs		B3KRR8 E9PDU5 Q9H9M3 Q9NNW5	B2R6D8 B3KUS7 Q9H3Q1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Polyubiquitination Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Liver Regeneration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Depolarization During Action Potential Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Negative Regulation Of Membrane Protein Ectodomain Proteolysis Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Organelle Organization Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Pseudopodium Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Regulation Of Cytoskeleton Organization Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Protein Ubiquitination Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair Positive Regulation Of Protein Acetylation Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Sodium Ion Transmembrane Transporter Activity Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production G2 DNA Damage Checkpoint	Regulation Of Filopodium Assembly Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Regulation Of Protein Binding Positive Regulation Of Gene Expression Positive Regulation Of Filopodium Assembly Regulation Of Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis Angiogenesis Positive Regulation Of Neuron Apoptotic Process Blood Vessel Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Neuron Fate Commitment Regulation Of ERBB Signaling Pathway Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nuclear Speck Organization Regulation Of Synapse Structure Or Activity Blood Vessel Development Vasculature Development Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Establishment Of Protein Localization Cell Cycle Arrest Response To Wounding Submandibular Salivary Gland Formation Collateral Sprouting In Absence Of Injury Actin Filament Branching Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Protein Localization Regulation Of Kinase Activity
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