WDR6 and G2E3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WDR6	G2E3
Description		WD repeat domain 6	G2/M-phase specific E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane COP9 Signalosome	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	TRNA Binding RNA Binding Protein Binding Enzyme Regulator Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Wobble Position Ribose Methylation TRNA Processing Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation G1 To G0 Transition	Apoptotic Process Protein Ubiquitination
Pathways		RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Menarche (age at onset) ( 25231870) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cognitive decline (age-related) ( 28078323)
Interacting Genes		6 interacting genes: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 UBC	4 interacting genes: LST1 RPS15 TRIM54 WDR6
Entrez ID		11180	55632
HPRD ID		06912	13851
Ensembl ID		ENSG00000178252	ENSG00000092140
Uniprot IDs		A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5	B4DIF9 B4DL73 F5GX24 Q49AD9 Q7L622
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Fatty Acid Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Lipid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Intracellular Signal Transduction Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Regulation Of Fatty Acid Metabolic Process Response To Vitamin B3 SREBP-SCAP Complex Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body BRCA1-B Complex Post-translational Protein Modification Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Regulation Of Anatomical Structure Morphogenesis BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Regulation Of Ketone Metabolic Process Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation DNA Strand Resection Involved In Replication Fork Processing Ubiquitin-protein Transferase Activity Regulation Of Lipid Biosynthetic Process Protein Ubiquitination DNA Repair Complex Random Inactivation Of X Chromosome Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Protein Tag Activity Sterol Binding Response To Sterol Depletion Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Endomembrane System Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
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