WDR6 and G2E3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WDR6	G2E3
Gene Name		WD repeat domain 6	G2/M-phase specific E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane COP9 Signalosome	Nucleolus Cytoplasm
	Molecular Function	Protein Binding Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy	Protein Polyubiquitination Blastocyst Development Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BRCA1 CDC42EP4 G2E3 PTPN3	3 interactors: LST1 RPS15 WDR6
Entrez ID		11180	55632
HPRD ID		06912	13851
Ensembl ID		ENSG00000178252	ENSG00000092140
Uniprot IDs		B3KRR8 E9PDU5 Q9H9M3 Q9NNW5	B4DIF9 F5GX24 Q7L622
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Polyubiquitination Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Liver Regeneration Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Depolarization During Action Potential Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Negative Regulation Of Membrane Protein Ectodomain Proteolysis Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Organelle Organization Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Pseudopodium Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Histone Methylation Regulation Of Cytoskeleton Organization Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Protein Ubiquitination Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair Positive Regulation Of Protein Acetylation Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Sodium Ion Transmembrane Transporter Activity Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production G2 DNA Damage Checkpoint	Ribosomal Small Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Ribosomal Small Subunit Assembly Sodium-independent Organic Anion Transport Negative Regulation Of Cell Proliferation
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