CLASP2 and PYGM

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		CLASP2	PYGM
Description		cytoplasmic linker associated protein 2	glycogen phosphorylase, muscle associated
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Cell Leading Edge Ruffle Membrane Cell Projection Axonal Growth Cone Basal Cortex Mitotic Spindle Glutamatergic Synapse Cortical Microtubule Plus-end	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding Actin Filament Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Regulation Of Axon Extension Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process Regulation Of Actin Cytoskeleton Organization Microtubule Anchoring Platelet-derived Growth Factor Receptor-beta Signaling Pathway Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Presynaptic Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs			Pyridoxal phosphate Beta-D-Glucopyranose Spirohydantoin (5S,7R,8S,9S,10R)-3-Amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione alpha-D-glucose 6-phosphate N-beta-D-glucopyranosylacetamide Monofluorophosphate ion Beta-D-Glucose 3,8,9,10-tetrahydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Nojirimycine Tetrazole Indirubin-5-sulphonate 2-Deoxy-Glucose-6-Phosphate C-(1-hydrogyl-beta-D-glucopyranosyl) formamide alpha-D-glucopyranosyl-2-carboxylic acid amide alpha-D-glucose-1-phosphate 8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole N-acetyl-N'-beta-D-glucopyranosyl urea 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole CP-320626 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester 8,9,10-trihydroxy-7-hydroxymethyl-3-methyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Alvocidib 1-deoxy-1-methoxycarbamido-beta-D-glucopyranose N-[(5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-(hydroxymethyl)-2,4-dioxo-6-oxa-1,3-diazaspiro[4.5]dec-3-yl]acetamide 1-Deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium N(6)-(pyridoxal phosphate)-L-lysine Heptulose-2-Phosphate N-(Benzoylcarbamoyl)-beta-D-glucopyranosylamine Dexfosfoserine 1-Deoxy-1-acetylamino-beta-D-gluco-2-heptulopyranosonamide Inosinic Acid 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL ({[(3E)-2'-Oxo-2',7'-dihydro-2,3'-biindol-3(7H)-ylidene]amino}oxy)acetic acid (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)	Urate levels ( 21768215)
Interacting Genes		15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CREBBP CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 PYGM RBFOX2 SRPK2	28 interacting genes: AGTPBP1 ARID1B CDC42BPB CLASP2 DNM2 FAM110A IGBP1 INTS4 LMNA NIPSNAP2 NTAQ1 PDE4DIP POMP PPP1CA PPP1R3B PPP2CA PRKAB2 PYGL S100A1 SGCG SRP72 TOP1 TRAPPC2 TRIM54 TRIM55 TRIM63 TTN WWP1
Entrez ID		23122	5837
HPRD ID		12054	01986
Ensembl ID		ENSG00000163539	ENSG00000068976
Uniprot IDs		A0A0U1RQI6 A0A804HJG7 E7ERI8 E7EW49 J3KR49 O75122	P11217
PDB IDs		3WOY 5NR4 8WHH 8WHI 8WHJ 8WHK 8WHL	1Z8D
Enriched GO Terms of Interacting Partners?		Microtubule Plus-end Binding Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Macroautophagy Regulation Of Microtubule-based Process Negative Regulation Of Macroautophagy Microtubule Regulation Of Autophagy Regulation Of Organelle Organization Negative Regulation Of Autophagosome Assembly Regulation Of Cellular Component Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microtubule Binding Protein Localization To Microtubule Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Localization To Organelle Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Organization Spindle Midzone Negative Regulation Of Catabolic Process Identical Protein Binding Positive Regulation Of Cell Growth 14-3-3 Protein Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Intracellular Signal Transduction Cell Cortex Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Organelle Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Peptidyl-serine Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Intracellular Signaling Cassette Negative Regulation Of Translational Initiation Protein Kinase Activity Regulation Of TRNA Methylation Regulation Of Transcription By RNA Polymerase I Neuron Projection Guidance Axon Guidance Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Protein Localization To Cytoskeleton Protein Localization To Astral Microtubule Response To Epidermal Growth Factor Cytoplasmic Microtubule Positive Regulation Of Growth	RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cortical Microtubule Plus-end Regulation Of Carbohydrate Catabolic Process M Band Cytoplasm Regulation Of Microtubule Polymerization Or Depolymerization Glycogen Granule Regulation Of Microtubule-based Process Regulation Of Glycogen Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Z Disc Glycogen Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Microtubule Energy Reserve Metabolic Process Protein Phosphatase Type 1 Complex Polysaccharide Metabolic Process Cytosol Microtubule-based Process Positive Regulation Of Glycogen Biosynthetic Process INTAC Complex Microtubule Organizing Center Organization Response To Lead Ion Negative Regulation Of Glycolytic Process RNA Polymerase II Transcription Initiation Surveillance Organelle Organization Protein Phosphatase 1 Binding Negative Regulation Of ATP Metabolic Process I Band Actomyosin Structure Organization Establishment Of Organelle Localization Regulation Of Glycogen Biosynthetic Process Cytoskeleton Organization Protein Modification Process Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Microtubule Depolymerization RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Phosphoprotein Phosphatase Activity Nuclear RNA Surveillance Regulation Of Microtubule Depolymerization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Membrane Tubulation Centrosome Cycle Vesicle Scission Cytoskeleton Positive Regulation Of High Voltage-gated Calcium Channel Activity Protein Phosphatase Regulator Activity
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