CLASP2

Description		cytoplasmic linker associated protein 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Cell Leading Edge Ruffle Membrane Cell Projection Axonal Growth Cone Basal Cortex Mitotic Spindle Glutamatergic Synapse Cortical Microtubule Plus-end
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding Actin Filament Binding Protein Tyrosine Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Regulation Of Axon Extension Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process Regulation Of Actin Cytoskeleton Organization Microtubule Anchoring Platelet-derived Growth Factor Receptor-beta Signaling Pathway Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Presynaptic Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CREBBP CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 PYGM RBFOX2 SRPK2
Entrez ID		23122
HPRD ID		12054
Ensembl ID		ENSG00000163539
Uniprot IDs		A0A0U1RQI6 A0A804HJG7 E7ERI8 E7EW49 J3KR49 O75122
PDB IDs		3WOY 5NR4 8WHH 8WHI 8WHJ 8WHK 8WHL
Enriched GO Terms of Interacting Partners?		Microtubule Plus-end Binding Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Macroautophagy Regulation Of Microtubule-based Process Negative Regulation Of Macroautophagy Microtubule Regulation Of Autophagy Regulation Of Organelle Organization Negative Regulation Of Autophagosome Assembly Regulation Of Cellular Component Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microtubule Binding Protein Localization To Microtubule Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Localization To Organelle Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Organization Spindle Midzone Negative Regulation Of Catabolic Process Identical Protein Binding Positive Regulation Of Cell Growth 14-3-3 Protein Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Intracellular Signal Transduction Cell Cortex Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Organelle Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Peptidyl-serine Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Intracellular Signaling Cassette Negative Regulation Of Translational Initiation Protein Kinase Activity Regulation Of TRNA Methylation Regulation Of Transcription By RNA Polymerase I Neuron Projection Guidance Axon Guidance Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Protein Localization To Cytoskeleton Protein Localization To Astral Microtubule Response To Epidermal Growth Factor Cytoplasmic Microtubule Positive Regulation Of Growth
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