CLASP2 and CLIP2

Number of citations of the paper that reports this interaction (PubMedID 11290329)
0

Data Source:
HPRD (two hybrid, in vitro)

		CLASP2	CLIP2
Description		cytoplasmic linker associated protein 2	CAP-Gly domain containing linker protein 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Cell Leading Edge Ruffle Membrane Cell Projection Axonal Growth Cone Basal Cortex Mitotic Spindle Glutamatergic Synapse Cortical Microtubule Plus-end	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Microtubule Plus-end
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding Actin Filament Binding Protein Tyrosine Kinase Binding	Microtubule Binding Microtubule Plus-end Binding
	Biological Process	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Regulation Of Axon Extension Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process Regulation Of Actin Cytoskeleton Organization Microtubule Anchoring Platelet-derived Growth Factor Receptor-beta Signaling Pathway Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Presynaptic Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis	Cytoplasmic Microtubule Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)	Age at suicide ( 31476763) Autism spectrum disorders (social interaction) ( 32624584) SAPHO syndrome ( 33816493)
Interacting Genes		15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CREBBP CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 PYGM RBFOX2 SRPK2	4 interacting genes: CLASP2 DYNLL1 ITSN1 MAX
Entrez ID		23122	7461
HPRD ID		12054	09140
Ensembl ID		ENSG00000163539	ENSG00000106665
Uniprot IDs		A0A0U1RQI6 A0A804HJG7 E7ERI8 E7EW49 J3KR49 O75122	A0A140VJG6 A7E2F7 Q9UDT6
PDB IDs		3WOY 5NR4 8WHH 8WHI 8WHJ 8WHK 8WHL	2CP2 2CP3
Enriched GO Terms of Interacting Partners?		Microtubule Plus-end Binding Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Macroautophagy Regulation Of Microtubule-based Process Negative Regulation Of Macroautophagy Microtubule Regulation Of Autophagy Regulation Of Organelle Organization Negative Regulation Of Autophagosome Assembly Regulation Of Cellular Component Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microtubule Binding Protein Localization To Microtubule Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Localization To Organelle Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Organization Spindle Midzone Negative Regulation Of Catabolic Process Identical Protein Binding Positive Regulation Of Cell Growth 14-3-3 Protein Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Intracellular Signal Transduction Cell Cortex Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Organelle Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Peptidyl-serine Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Intracellular Signaling Cassette Negative Regulation Of Translational Initiation Protein Kinase Activity Regulation Of TRNA Methylation Regulation Of Transcription By RNA Polymerase I Neuron Projection Guidance Axon Guidance Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Protein Localization To Cytoskeleton Protein Localization To Astral Microtubule Response To Epidermal Growth Factor Cytoplasmic Microtubule Positive Regulation Of Growth	Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Myc-Max Complex Mad-Max Complex Positive Regulation Of Peptide Hormone Secretion Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Peptide Secretion Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis Cortical Microtubule Plus-end Positive Regulation Of Hormone Secretion Deoxyribonuclease Inhibitor Activity Mitotic Spindle Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Kinetochore Cortical Microtubule Cytoskeleton Positive Regulation Of Transport Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Peptide Hormone Secretion Basal Cortex Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Hormone Secretion Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Nitric-oxide Synthase Regulator Activity Presynaptic Cytoskeleton Organization Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Basement Membrane Organization Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Extracellular Matrix Disassembly Dystroglycan Binding Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of DNA-templated DNA Replication Cell Projection Regulation Of Growth Hormone Secretion Intraciliary Retrograde Transport Microtubule Positive Regulation Of Developmental Process Regulation Of Modification Of Postsynaptic Structure Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Regulation Of Gastrulation Exit From Mitosis
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