HARS2 and AGTRAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		HARS2	AGTRAP
Description		histidyl-tRNA synthetase 2, mitochondrial	angiotensin II receptor associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	Angiotensin Type II Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Mitochondrial Translation	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway
Pathways		Mitochondrial tRNA aminoacylation	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Basophil percentage of white cells ( 32888494) Systolic blood pressure ( 19430483)
Interacting Genes		22 interacting genes: AGTRAP BST2 MIR106B MIR128-2 MIR141 MIR145 MIR16-2 MIR17 MIR18B MIR199A1 MIR19B1 MIR19B2 MIR29A MIR29B1 MIR34A MIR34B MIR9-1 MIR92A2 MIR93 MIRLET7F1 MIRLET7I OGT	138 interacting genes: ACSF2 AGTR1 AGTR2 ALDH18A1 ANKS6 AP3M1 APOA4 AQP6 ARAF ARFIP2 ARHGAP1 ATP5F1E BCL2L13 BPIFA2 CAPNS1 CCDC70 CD160 CD79A CELA3A CIAO2A COQ8A CPLX1 CPLX4 CRCT1 CYB5R3 CYBC1 DDA1 DDX55 DGCR6 DIABLO DNAJC1 ECPAS ERGIC3 ETFRF1 FAM114A1 FAM209A FARS2 FASTKD3 FATE1 FFAR2 FGA FHIP1B FNDC9 GABARAPL2 GAD1 GAD2 GDNF GPR152 GPX8 GTF2H1 GTF3C1 H4C7 HARS2 HIBADH HMGB1 HSBP1L1 HSCB HSD17B13 HSFX1 HSFX2 HSPA4 IL7R ISCU KCNK5 KIR2DL3 KIR3DL3 LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MGST3 MIEF1 MIEF2 MMD MRM1 MRPL11 MRRF MTERF3 MUTYH MYG1 NDRG4 NDUFAF3 NFU1 NFYB NKG7 PBX3 PCTP PCYT1A PDHX PIMREG PITPNC1 PNPO POLDIP2 PPIF PRPF18 PTPN9 RAB30 RACK1 RBFA RETREG3 RMDN2 S100B SCAND1 SENP2 SH3GLB1 SLC18A1 SLC7A14 SMG9 SNX1 SPG21 SSX3 SSX5 STAG3L1 STAR STARD4 STMN4 STX1A SUCLA2 SYT16 TBRG4 TCEA2 TCEANC2 TFAM THAP4 TMEM139 TMEM14B TMEM31 TMPPE TPD52L3 TTPA TUBA1B TXN2 UBE2I YARS2 ZFYVE21 ZNF391
Entrez ID		23438	57085
HPRD ID		02871	16379
Ensembl ID		ENSG00000112855	ENSG00000177674
Uniprot IDs		A0A2R8Y5P7 A0A2R8Y6I1 B4DDN8 P49590	Q6RW13
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cholesterol Efflux Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Developmental Process MRNA Destabilization Regulation Of Translation RNA Destabilization Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cholesterol Transport Positive Regulation Of MRNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Extracellular Matrix Assembly Regulation Of Gene Expression Positive Regulation Of Connective Tissue Replacement Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Lipid Transport Negative Regulation Of Transport Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Connective Tissue Replacement Regulation Of Cholesterol Efflux Regulation Of MRNA Stability Negative Regulation Of Cell Communication	Mitochondrial Matrix Mitochondrion Protein Binding Lipid Binding Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity
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