AP4E1 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 11707398)
73

Data Source:
HPRD (in vivo)

		AP4E1	ARF1
Description		adaptor related protein complex 4 subunit epsilon 1	ARF GTPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane Membrane Coat AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Protein Binding Cargo Adaptor Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases		Cerebral palsy
GWAS		Chloride levels ( 29403010) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Height ( 31562340) Keratoconus ( 33649486) Potassium levels ( 29403010) Response to fenofibrate (HDL cholesterol levels) ( 27002377)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		3 interacting genes: AP4B1 ARF1 MTNR1B	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		23431	375
HPRD ID		06258	00054
Ensembl ID		ENSG00000081014	ENSG00000143761
Uniprot IDs		B4DM48 Q9UPM8	P84077
PDB IDs			1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Cleavage Furrow Ingression Mitotic Cleavage Furrow Ingression Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane Protein Localization To Somatodendritic Compartment Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep AP-4 Adaptor Complex Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Clathrin Adaptor Complex Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Negative Regulation Of Cytosolic Calcium Ion Concentration Long-chain Fatty Acid Transmembrane Transporter Activity Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell Regulation Of Transmission Of Nerve Impulse Copper Ion Homeostasis Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle Endosome Lumen Bile Acid Biosynthetic Process Intracellular Protein Transport Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Behavior Membrane Coat Dendritic Spine Organization Bile Acid Metabolic Process Regulation Of Actin Nucleation	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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