AP4E1

Description		adaptor related protein complex 4 subunit epsilon 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Membrane Membrane Coat AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Cargo Adaptor Activity
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Cerebral palsy
GWAS		Chloride levels ( 29403010) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Height ( 31562340) Keratoconus ( 33649486) Potassium levels ( 29403010) Response to fenofibrate (HDL cholesterol levels) ( 27002377)
Novel Interacting Genes		1 novel interacting genes: SLC27A2
Interacting Genes		3 interacting genes: AP4B1 ARF1 MTNR1B
Entrez ID		23431
HPRD ID		06258
Ensembl ID		ENSG00000081014
Uniprot IDs		B4DM48 Q9UPM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cleavage Furrow Ingression Mitotic Cleavage Furrow Ingression Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane Protein Localization To Somatodendritic Compartment Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep AP-4 Adaptor Complex Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Clathrin Adaptor Complex Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Negative Regulation Of Cytosolic Calcium Ion Concentration Long-chain Fatty Acid Transmembrane Transporter Activity Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell Regulation Of Transmission Of Nerve Impulse Copper Ion Homeostasis Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle Endosome Lumen Bile Acid Biosynthetic Process Intracellular Protein Transport Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Behavior Membrane Coat Dendritic Spine Organization Bile Acid Metabolic Process Regulation Of Actin Nucleation
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