CBX2 and RBMY1A1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CBX2	RBMY1A1
Description		chromobox 2	RNA binding motif protein Y-linked family 1 member A1
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GO Annotations	Cellular Component	Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Sex Differentiation Cell Differentiation Development Of Primary Sexual Characteristics	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: BOLL CYSRT1 DHX57 H3-3A H3-4 H3C1 H3C14 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63	29 interacting genes: AEN APOBEC3C CBX2 CIRBP CLK3 DAAM2 DHX57 HBZ HNRNPK KHDRBS3 LMNTD2 LNX1 MYPOP PCDHB14 PRPF31 PRR3 RASD1 RBM3 RBMX RBMY1F RBMY1J SNRPA SRSF3 SRSF9 TERF1 TH TRA2B YTHDC1 ZNF317
Entrez ID		84733	5940
HPRD ID		14397	02450
Ensembl ID		ENSG00000173894	ENSG00000234414
Uniprot IDs		Q14781	P0DJD3
PDB IDs		2D9U 3H91 5EPK	2FY1
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Chromatin Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Nucleosome Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleosome Positive Regulation Of RNA Splicing Nucleosome Organization Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Protein-DNA Complex Assembly Hair Cycle Identical Protein Binding Positive Regulation Of MRNA Metabolic Process Protein Heterodimerization Activity Chromatin Remodeling Spliceosomal Complex	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing Nucleic Acid Binding Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Binding MRNA Processing Positive Regulation Of RNA Splicing RNA Splicing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Positive Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Negative Regulation Of RNA Splicing Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Pre-mRNA Binding Negative Regulation Of Macromolecule Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Gene Expression Nuclear Speck Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere
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