ADAMTS13

Description		ADAM metallopeptidase with thrombospondin type 1 motif 13
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Glycoprotein Metabolic Process Response To Toxic Substance Response To Amine Protein Processing Protein Catabolic Process Platelet Activation Extracellular Matrix Organization Response To Type II Interferon Response To Tumor Necrosis Factor Response To Potassium Ion Peptide Catabolic Process Response To Interleukin-4 Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins Platelet Adhesion to exposed collagen Enhanced cleavage of VWF variant by ADAMTS13 Defective VWF cleavage by ADAMTS13 variant
Drugs
Diseases		Thrombotic thrombocytopenic purpura; Moschcowitz disease; Schulman-Upshaw syndrome
GWAS		Activated partial thromboplastin time ( 22703881) ADAMTS13 activity ( 25934476) ADAMTS13 levels ( 29296746) Circulating fibroblast growth factor 23 levels ( 30217807) Coagulation factor levels ( 23267103) Cobalt levels ( 26025379) Gut microbiota (functional units) ( 27694959) Liver enzyme levels ( 18940312) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Pancreatic cancer ( 25086665) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Novel Interacting Genes		2 novel interacting genes: EXOSC2 WDR5
Interacting Genes		1 interacting genes: VWF
Entrez ID		11093
HPRD ID		04994
Ensembl ID		ENSG00000160323
Uniprot IDs		Q76LX8
PDB IDs		3GHM 3GHN 3VN4 6QIG 7B01
Enriched GO Terms of Interacting Partners?		Immunoglobulin Binding Weibel-Palade Body Set1C/COMPASS Complex NSL Complex Histone H3Q5ser Reader Activity MLL3/4 Complex Histone H3K4 Methyltransferase Activity ATAC Complex MLL1/2 Complex Histone H3K4me1 Reader Activity Cytoplasmic Exosome (RNase Complex) Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Exonuclease Activity U4 SnRNA 3'-end Processing CUT Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Platelet Alpha Granule SnRNA 3'-end Processing Positive Regulation Of Gluconeogenesis Histone Acetyltransferase Complex Histone Methyltransferase Complex 3'-5'-RNA Exonuclease Activity MLL1 Complex SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Gluconeogenesis Regulation Of Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling SnRNA Metabolic Process Hexose Biosynthetic Process Platelet Alpha Granule Lumen Collagen Binding Platelet Activation
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