TNFSF10 and TNFRSF10D

Number of citations of the paper that reports this interaction (PubMedID 9430226)
0

Data Source:
HPRD (in vitro, in vivo)

		TNFSF10	TNFRSF10D
Description		TNF superfamily member 10	TNF receptor superfamily member 10d
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding TRAIL Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Signaling TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Negative Regulation Of Apoptotic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling	Cell surface interactions at the vascular wall TP53 Regulates Transcription of Death Receptors and Ligands TRAIL signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver volume ( 34128465) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Attention deficit hyperactivity disorder ( 20732625) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		10 interacting genes: ACP5 CASP3 CFTR RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17	28 interacting genes: APOL3 ARFIP1 CIAO2A ECPAS FAM114A1 GAD2 HSBP1L1 INPP5K LAT MIEF1 MTERF4 PCYT1A PITPNC1 PLPP6 POLL RBP1 RMDN2 SEMA4G SENP2 SLC39A7 SUCLA2 TARS2 TBRG4 THAP4 TNFRSF10A TNFRSF10B TNFSF10 TUFM
Entrez ID		8743	8793
HPRD ID		04670	04682
Ensembl ID		ENSG00000121858	ENSG00000173530
Uniprot IDs		P50591 Q6IBA9	Q9UBN6
PDB IDs		1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?		TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Apoptotic Process Programmed Cell Death Activation Of NF-kappaB-inducing Kinase Activity Cell Surface Apoptotic Signaling Pathway Golgi-associated Vesicle Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity Signaling Receptor Activity Negative Regulation Of Superoxide Anion Generation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRAIL Receptor Activity Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Phospholipase A2 Activator Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protease Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Monoatomic Anion Transport Multicellular Organismal-level Homeostasis Anterior Neural Tube Closure Cellular Response To Staurosporine Positive Regulation Of Enamel Mineralization Positive Regulation Of Protein Kinase Activity Luteolysis Glial Cell Apoptotic Process Transepithelial Water Transport Positive Regulation Of Kinase Activity Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Immune System Process Acid Phosphatase Activity Response To Anesthetic Positive Regulation Of Tooth Mineralization Protein-cysteine S-stearoyltransferase Activity Ferric Iron Binding Death-inducing Signaling Complex	TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Lipid Phosphatase Activity Succinate Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Mitochondrial RNA Metabolic Process Activation Of NF-kappaB-inducing Kinase Activity
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