NUDCD3 and SPOP

Number of citations of the paper that reports this interaction (PubMedID 28805822)
55

Data Source:
BioGRID (two hybrid)

		NUDCD3	SPOP
Description		NudC domain containing 3	speckle type BTB/POZ protein
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GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Dynein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Unfolded Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity
	Biological Process	Protein Folding Cilium Assembly Protein Localization To Pericentriolar Material	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Iris color (b* coordinate) ( 30895295)	Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: CCNDBP1 KLHL20 KRTAP10-3 KRTAP10-7 SPOP UBE2I	74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		23386	8405
HPRD ID		13831	16004
Ensembl ID		ENSG00000015676	ENSG00000121067
Uniprot IDs		Q8IVD9	O43791
PDB IDs		1WGV	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity PML Body Cul3-RING Ubiquitin Ligase Complex Protein K33-linked Ubiquitination Type II Interferon Binding Keratin Filament RING-like Zinc Finger Domain Binding SUMO Ligase Complex Proteolysis Involved In Protein Catabolic Process HLH Domain Binding Protein Modification By Small Protein Conjugation Intermediate Filament Small Protein Activating Enzyme Binding Post-translational Protein Modification Mitotic Nuclear Membrane Reassembly Macromolecule Catabolic Process Protein Polyubiquitination Transferase Complex Golgi To Endosome Transport Proteolysis Nuclear Body Transcription Factor Binding SUMO Transferase Activity Response To Interferon-alpha Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Synaptonemal Complex Nuclear Membrane Reassembly Presynaptic Cytosol	Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding
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