DAZ1 and DAZL

Number of citations of the paper that reports this interaction (PubMedID 12511597)
35

Data Source:
BioGRID (two hybrid, pull down, two hybrid)
HPRD (in vitro)

		DAZ1	DAZL
Description		deleted in azoospermia 1	deleted in azoospermia like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Protein-containing Complex	Nucleus Cytoplasm Ribosome Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity Identical Protein Binding
	Biological Process	Spermatogenesis Cell Differentiation Positive Regulation Of Translational Initiation 3'-UTR-mediated MRNA Stabilization	Oocyte Maturation Regulation Of Translation Female Meiosis II Germ Cell Development Spermatogenesis Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Positive Regulation Of Translational Initiation 3'-UTR-mediated MRNA Stabilization
Pathways
Drugs
Diseases
GWAS			Feeling fed-up ( 29500382) Intelligence ( 28530673) Lung cancer ( 28604730) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Smoking initiation ( 33082346) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)
Interacting Genes		10 interacting genes: BOLL DAZAP1 DAZAP2 DAZL DYNLL1 DZIP1 DZIP1L DZIP3 PUM2 QKI	5 interacting genes: DAZ1 DAZ4 DAZAP1 DAZAP2 PUM2
Entrez ID		1617	1618
HPRD ID		15958	09029
Ensembl ID		ENSG00000188120	ENSG00000092345
Uniprot IDs		A0A140VJH5 Q9NQZ3	A0A140VK77 Q92904
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA 3'-UTR Binding Regulation Of MRNA Metabolic Process Organelle Assembly Stress Granule Assembly Regulation Of MRNA Stability Germ Cell Development Developmental Process Involved In Reproduction Regulation Of RNA Stability MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of RNA Catabolic Process Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Translation Activator Activity Reproductive Process 3'-UTR-mediated MRNA Stabilization Regulation Of Translation Positive Regulation Of MRNA Metabolic Process RNA Binding Male Gamete Generation Spermatogenesis Organelle Organization Cytoplasm Gamete Generation MiRNA Binding Nucleic Acid Binding Post-transcriptional Regulation Of Gene Expression Motile Cilium Assembly Positive Regulation Of Translational Initiation Cilium Assembly Membraneless Organelle Assembly Cilium Organization Internal N(7)-methylguanine-containing RNA Reader Activity Protein Localization To Cilium Pumilio-response Element Binding Female Meiosis II Cell Development Negative Regulation Of Catabolic Process Cell Projection Assembly Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Cellular Component Assembly Plasma Membrane Bounded Cell Projection Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Smoothened Signaling Pathway BBSome Binding Protein-containing Complex Localization To Centriolar Satellite Positive Regulation Of Sprouting Of Injured Axon Regulation Of Nucleobase-containing Compound Metabolic Process	MRNA 3'-UTR Binding Regulation Of MRNA Metabolic Process Translation Activator Activity Regulation Of MRNA Stability Regulation Of RNA Stability 3'-UTR-mediated MRNA Stabilization Protein-containing Complex Stress Granule Assembly Positive Regulation Of Translational Initiation Regulation Of Translation MRNA Stabilization Male Gamete Generation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process Spermatogenesis RNA Stabilization RNA Binding Gamete Generation Negative Regulation Of RNA Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Pumilio-response Element Binding Negative Regulation Of MRNA Metabolic Process Nucleic Acid Binding Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Sprouting Of Injured Axon Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Translation Developmental Process Involved In Reproduction Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular MRNA Localization Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Biological Quality Poly(G) Binding Positive Regulation Of Biosynthetic Process Membraneless Organelle Assembly Positive Regulation Of Axon Regeneration Maternal Placenta Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing Reproductive Process Negative Regulation Of Catabolic Process Mitogen-activated Protein Kinase Kinase Kinase Binding
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