HAUS5 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		HAUS5	RGS2
Description		HAUS augmin like complex subunit 5	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule HAUS Complex Mitotic Spindle Microtubule	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding
	Biological Process	Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	G alpha (q) signalling events
Drugs
Diseases
GWAS			Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		2 interacting genes: RGS2 YAE1	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		23354	5997
HPRD ID		19389	02917
Ensembl ID		ENSG00000249115	ENSG00000116741
Uniprot IDs		O94927	P41220
PDB IDs		7SQK	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Negative Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Striated Muscle Contraction Adenylate Cyclase Inhibitor Activity Relaxation Of Cardiac Muscle Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Smooth Muscle Contraction Relaxation Of Muscle Negative Regulation Of Muscle Contraction Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth Brown Fat Cell Differentiation G-protein Alpha-subunit Binding Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Muscle Hypertrophy Negative Regulation Of JNK Cascade Response To Amphetamine Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Organ Growth Positive Regulation Of Heart Contraction Maternal Process Involved In Female Pregnancy Beta-tubulin Binding Negative Regulation Of Cardiac Muscle Hypertrophy Response To Amine Positive Regulation Of Muscle Contraction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Regulation Of Amine Transport Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Cell Differentiation Regulation Of Organ Growth Negative Regulation Of Developmental Growth Regulation Of Striated Muscle Contraction Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Transmembrane Transport Response To Ethanol Fat Cell Differentiation Regulation Of JNK Cascade Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Regulation Of G Protein-coupled Receptor Signaling Pathway	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity
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