GPX2 and PSMB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPX2	PSMB2
Gene Name		glutathione peroxidase 2 (gastrointestinal)	proteasome (prosome, macropain) subunit, beta type, 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Core Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	Glutathione Peroxidase Activity Electron Carrier Activity	Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Symbiotic Bacterium Interaction With Symbiont Oxidation-reduction Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Response To Organonitrogen Compound Gene Expression Response To Organic Cyclic Compound Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs		Glutathione
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MYC PSMB2 TP53	7 interactors: DDX49 GPX2 KCTD9 KRT13 PLK1 PSMA1 PSMB3
Entrez ID		2877	5690
HPRD ID		11818	03708
Ensembl ID		ENSG00000176153
Uniprot IDs		P18283	B7Z478 P49721
PDB IDs		2HE3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Response To Gamma Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cellular Response To Drug Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Mitotic DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Stem Cell Proliferation Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Signal Transduction Cellular Response To Radiation Notch Signaling Pathway Response To Ionizing Radiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Arrest DNA Damage Checkpoint Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Signaling Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest
Tagcloud ?		adapt adaptive ampk antioxidants avoids biogenesis comprehensively consumed crisis depolarization devoid etc fueling futile gpx1 gpx5 gr hampered handling paralleled peroxidation pgc1 prominently pumps slower sod1 sod2 strictly ultra	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated usp14
Tagcloud (Difference) ?		adapt adaptive ampk antioxidants avoids biogenesis comprehensively consumed crisis devoid etc fueling futile gpx1 gpx5 gr hampered handling paralleled peroxidation pgc1 prominently pumps slower sod1 sod2 strictly ultra	20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated usp14
Tagcloud (Intersection) ?		depolarization