DCTPP1 and ZNF668

		DCTPP1	ZNF668
Description		dCTP pyrophosphatase 1	zinc finger protein 668
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of Transcription By RNA Polymerase II
Pathways		Interconversion of nucleotide di- and triphosphates	Generic Transcription Pathway
Drugs
Diseases
GWAS		Urinary sodium excretion ( 31409800)	Body fat distribution (arm fat ratio) ( 30664634) Response to metformin (IC50) ( 28173075)
Interacting Genes		12 interacting genes: APP FMR1 FXR1 FXR2 LNX1 NIF3L1 NOA1 NTAQ1 PSMA1 SDCBP SPG21 USP7	8 interacting genes: BYSL HMGB2 PRPF31 VCX VHL ZNF165 ZNF250 ZNF792
Entrez ID		79077	79759
HPRD ID		18310	07828
Ensembl ID		ENSG00000179958	ENSG00000167394
Uniprot IDs		Q9H773	A8K1I4 Q96K58
PDB IDs		7MU5
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity	Nucleus Ribonucleoprotein Complex Localization DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Non-sequence-specific DNA Binding, Bending U4atac SnRNP Pyrimidine Deoxyribonucleotide Binding SnRNP Binding U4atac SnRNA Binding
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