FBXW11 and BHLHE40

Number of citations of the paper that reports this interaction (PMID 25202122)
0

Data Source:
BioGRID (enzymatic study)

		FBXW11	BHLHE40
Gene Name		F-box and WD repeat domain containing 11	basic helix-loop-helix family, member e40
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Golgi Apparatus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Activation of NF-kappaB in B cells G2/M Transition Class I MHC mediated antigen processing & presentation Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Adaptive Immune System	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Height ( 20881960 23563607)
Protein-Protein Interactions		14 interactors: AMER1 BHLHE40 BTRC CDC25A CUL1 GLI2 IFNAR1 KDR NFKB1 NFKBIA PRLR TRIM21 UBE2D3 WEE1	49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1
Entrez ID		23291	8553
HPRD ID		07294	16050
Ensembl ID		ENSG00000072803	ENSG00000134107
Uniprot IDs		B4DH70 Q9UKB1	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Stimulus Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Monoubiquitination Response To Organic Substance Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Cell Cycle Phase Transition Response To Abiotic Stimulus Mammary Gland Epithelium Development Signaling Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Biosynthetic Process Innate Immune Response Regulation Of Cellular Process Activation Of Innate Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Immune System Process Protein Destabilization G1/S Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Mammary Gland Development Protein Polyubiquitination Circadian Rhythm Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Innate Immune Response	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process
Tagcloud ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Difference) ?		adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Intersection) ?