COBL and PACSIN1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		COBL	PACSIN1
Gene Name		cordon-bleu WH2 repeat protein	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Monomer Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding
	Biological Process	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Type 1 diabetes ( 19430480) Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		1 interactors: PACSIN1	24 interactors: ANKRD24 ARHGAP17 ATP8 COBL COBLL1 DNM1 EHBP1 FTH1 GAS7 HTT JADE2 KAT7 KHDRBS1 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		23242	29993
HPRD ID		10843	05936
Ensembl ID		ENSG00000106078	ENSG00000124507
Uniprot IDs		O75128	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?		Membrane Tubulation Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Negative Regulation Of Endocytosis Positive Regulation Of Dendrite Development Establishment Of Protein Localization To Plasma Membrane Regulation Of Dendrite Development Synaptic Vesicle Transport	Cell Projection Morphogenesis Cell Part Morphogenesis Actin Filament-based Process Endocytosis Cellular Component Assembly Vesicle-mediated Transport Cell Morphogenesis Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Organization Cell Projection Organization Actin Cytoskeleton Organization Neuron Development Neuron Projection Morphogenesis Regulation Of Endocytosis Actin Filament-based Movement Endomembrane System Organization Generation Of Neurons Neuron Differentiation Histone H4-K12 Acetylation Membrane Tubulation Neurogenesis Neuron Projection Development Actin Polymerization Or Depolymerization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Axonogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Protein Polymerization Anatomical Structure Morphogenesis Axon Development Regulation Of Cellular Process Regulation Of Protein Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Organization Cell Morphogenesis Involved In Neuron Differentiation Membrane Assembly Regulation Of Cell Projection Assembly Regulation Of Protein Complex Disassembly Protein Complex Assembly Movement Of Cell Or Subcellular Component Cellular Protein Complex Assembly Membrane Biogenesis Cell Differentiation Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Complex Disassembly Cell Morphogenesis Involved In Differentiation Axon Guidance
Tagcloud ?		actin apical asap1 associate bar basal base believed bleu cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Difference) ?		actin apical asap1 associate bar basal base believed bleu cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Intersection) ?